Postdoctoral Scientist in Molecular and Cell biology of Sarcoma Neoantigen pMHC-TCR Interactions

Location : Sir William Dunn School of Pathology, South Parks Road, Oxford

We are seeking a highly motivated post-doctoral researcher with recent completion of their PhD/ DPhil for a post that bridges across research areas that include genomic informatics, neoantigen prediction, pMHC-TCR molecular and cellular functional immuno-oncology. The focus is on rare cancers associated with driver chromosomal translocations called sarcomas. The post is funded by collaborative translational grants that aim to develop the basic science and experimental basis for translation of pMHC-TCR interactions to personalised TCR and mRNA vaccines. The post-holder will be located at the Sir William Dunn School of Pathology and must be able to work independently within a multi-disciplinary research group and in collaboration with key project partners in the Centre for Immuno-Oncology in the Nuffield Department of Medicine (Dr Felipe Galvez-Cancino).

The post-holder will be responsible for managing their own academic research, adapting existing and developing new scientific techniques and experimental protocols. You will work to identify, develop, modify and apply the necessary techniques such as mammalian and bacterial protein expression, surface plasmon resonance and T-cell reporter assays to achieve the goals of the project. The post-holder should be able to present detailed research proposals to senior researchers, undertake comprehensive and systematic literature reviews and write up the results for publication in peer-reviewed journals, as well as present findings at external meetings, funder organisations and seminars.

The post-holder should either hold, or be very close to completion of, a PhD/DPhil directly relevant to this specific post preferably with experience equivalent to a post-doctoral level. You should have expertise in genomic and molecular computational-bioinformatic approaches in sarcoma, as well as direct experience with laboratory molecular and cell biology techniques with respect to either molecular immunology. You should have proven skills in working independently to solve experimental problems and be capable of high-quality research as demonstrated by significant research outputs through publications, patents and conference proceedings.

This is a fixed-term appointment available for up to 24 months starting from 1st February 2026 . If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for applications is 12 midday on Friday 23rd January 2026. Interviews will be held on the 26th January 2026 online.  Candidates will be asked to give a 10-minute research talk in the interview.  For further details, please contact Prof Bass Hassan via email: bass.hassan@path.ox.ac.uk.

At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers.

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