Research Fellow

Salary: Full time starting salary is normally in the range £36,636 to £46,049 with potential progression once in post to £48,822

Contract Type: Fixed Term contract up to February 2031

Background

To create and contribute to the creation of knowledge by undertaking a specified range of activities within an established research programme and/or specific research project.

This BBSRC (sLoLa) - funded post is established to study the semantic rules of developmental gene expression control. The post holder will be part of a multi-disciplinary consortium team (6 institutions in the UK) and work within the Department of Cancer and Genomic Sciences. Their main role will be to apply and develop new methods for precise genome manipulation to create transgenic reporter models for asking questions about transcriptional regulation mechanisms of developmental gene expression. They will apply molecular phenotyping approaches such as high resolution genomics technologies in zebrafish embryo models. They will perform and develop cell resolution genomics assays (e.g. CAGE-seq and ATAC-seq) for analysing gene expression and gene regulatory element dynamics. They lead the Birmingham subteam including supervision of PhD student(s) and will work in close collaboration with experts at Edinburg University, Imperial, Manchester University and other partners in computational biology, genome editing and genome synthesis technologies. The post is available for 3 years in the first instance.

Role Summary

• Work within specified research grants and projects and contribute to writing bids 
• Operate within area of functional genomics and developmental genetics
• Analyse and interpret research findings and results by embryo phenotyping by genomics and imaging tools, publish high quality new results in peer reviewed journals 

Main Duties

The responsibilities may include some but not all of the responsibilities outlined below.

• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Analyse and interpret genomics, embryo phenotyping and developmental genetic data
• Apply knowledge in a way which develops new intellectual understanding of transcription control
• Disseminate research findings for peer reviewed publication, research seminars conferences and consortium meetings 
• Supervise junior colleagues including PhD students on wet lab research and provide guidance where appropriate to the developmental genetics, functional genomics
• Develop new models, techniques and methods in genome editing and manipulation, in vivo phenotyping 

Person Specification

• First degree in biology or related subject and normally, a PhD in biomedical research area or equivalent qualifications
• High level analytical capability
• Ability to communicate complex information clearly
• Fluency in embryo model (preferably zebrafish) associated genome manipulation techniques and ability to contribute to developing new ones including base and prime editing, site specific recombination technologies
• Fluency in genetic manipulation tools applied in developmental genetics

Informal enquiries to Ferenc Mueller, email: f.mueller@bham.ac.uk 

To download the full job description and details of this position and submit an electronic application online please click on the 'Apply' button above.

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