PhD Studentship: How immune dysregulation contributes to cancer progression in Myeloma

Primary supervisor - c.hellmich@uea.ac.uk

Background

Approximately 6,000 people are diagnosed with myeloma in the UK each year. It is always preceded by the pre-malignant condition monoclonal gammopathy of undetermined significance (MGUS). However, only 1% of patients with MGUS will develop myeloma every year. Despite advances in treatments, myeloma continues to be associated with significant morbidity and mortality. Understanding the mechanism that drives the progression of MGUS to myeloma is therefore key in preventing development of this incurable cancer. 

Changes in both the adaptive and innate immune system have been observed in patients with MGUS and myeloma. We hypothesise that these changes directly contribute to the progression of MGUS to myeloma. By investigating the underlying mechanism that drives this we plan to identify therapeutic targets that could prevent the progression of MGUS to myeloma. 

Research Methodology

This PhD project will investigate changes in the innate immune system in MGUS and myeloma and how they contribute to disease progression. This will lead to potential identification of pathways that could be targeted to reduce or prevent disease progression. To do this, the PhD student will learn in vivo techniques including animal handling, as well as isolation of samples from humans. The student will receive training in cellular biology methodologies including tissue culture, molecular techniques including DNA and RNA isolation, flow cytometry and metabolomics. 

Training and Supervision

The project will be supervised by Dr Hellmich and Prof Rushworth (Norwich Medical School). Dr Hellmich is a clinical researcher with direct access to primary patient samples, while Prof Rushworth has successfully supervised ten PhD students, all of whom progressed to postdoctoral positions. The laboratory provides a supportive and collaborative environment, with weekly lab meetings, journal clubs, and strong encouragement to present at local, national, and international conferences.

This project offers the opportunity to develop advanced research skills in immunology, in vivo modelling and metabolomics alongside transferable skills essential for future career development.

Entry requirements

The minimum entry requirement is 2:1 (any degree with a substantial biological sciences component).

Mode of study

Full-time

Start date

1 October 2026

Additional Funding Information

This project is fully funded for 3 years. Funding includes tuition fees, an annual tax-free maintenance allowance and a research training support budget.

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