Research Assistant - Modelling ALS in iPSCs and Transcriptomics of Derived Neurons

Location: Centre for Human Genetics, Building for Genomic Medicine, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7BN

We are seeking to appoint a Research Assistant to join the Nuffield Department of Medicine to work on modelling Amyotrophic Lateral Sclerosis (ALS) using induced pluripotent stem cells (iPSCs) and transcriptomic analysis of derived neurons. The project investigates transcriptomic changes linked to early stages of Motor Neuron Disease (MND) and ALS, focusing on the misregulation of TDP-43 and associated RNA processing defects. The work aims to identify and validate transcriptomic changes, potential drug targets and biomarkers, and to develop and optimise neuronal models to characterise disease mechanisms.

You will be responsible for the culture and characterisation of iPSC-derived neuronal models and the generation of novel cell lines using CRISPR-Cas9 genome editing. You will utilise mRNA- and iCLIP-sequencing approaches to analyse RNA expression and regulation changes, undertake cellular and biochemical assays using advanced cell and molecular biology and imaging techniques, and conduct a small molecule screen in collaboration with the Oxford Drug Discovery Institute. You will design, test and optimise antisense oligonucleotides to alter RNA processing defects, contribute to data analysis and interpretation with support from bioinformatics and imaging teams, and assist in scientific reports, publications and presentations. The role also includes adapting and developing experimental protocols, contributing to laboratory management and collaborative projects, and complying with health and safety regulations.

It is essential that you hold an MSc degree in Neuroscience, Biology, Molecular Biology, Biochemistry, Biomedical Sciences, Genetics/Genomics or a related area and have experience and knowledge of neurodegenerative diseases such as ALS. You must have experience in iPSC-derived neuron culture and sterile technique, prior knowledge of conducting small molecule screens, and experience in molecular biology techniques including cloning, RT-PCR, immunoblotting, immunofluorescence and microscopy. You should be highly motivated, able to interpret and optimise experimental work, work collaboratively across teams, and demonstrate excellent communication skills including presenting research results in laboratory and external meetings.

Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

This position is offered full time on a fixed term contract for 2 years and is funded by the MND Association.

Only applications received before 12 midday on 31 March 2026 will be considered. Please quote 184993 on all correspondence.

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