Research Technician

Location: Vascular Science, National Heart and Lung Institute, Hammersmith Campus

About the role:

We are seeking a highly motivated individual to join Prof. Ramzi Khamis’ team in a research technician position funded by the Safwan Sobhan Programme. This position is available for 24 months.

Prof. Khamis is a Consultant Cardiologist and Reader at Imperial College London. His research team consists of clinicians and scientists, focusing on the targeting of oxidised-LDL, a key driver of atherosclerosis. We have developed antibodies that target oxidised-LDL and utilised them as imaging agents. In this post you will be responsible for managing a murine animal colony and conducting in vivo imaging in our murine model of atherosclerosis, and subsequent ex vivo analysis.

What you would be doing:

You will be based at the Imperial Centre for Translational and Experimental Medicine (ICTEM). You will be working on projects involving immunisation through anti-oxidised-LDL antibodies with in vivo imaging, immune biomarker determination from patient samples through ELISAs and immune cell isolation and culture for in vitro models of atherosclerosis. You will be responsible for:

• In vivo and ex vivo molecular imaging of atherosclerosis in multiple models and using multiple fluorescence based methods.
• Peripheral blood mononuclear cells (PBMCs) isolation and culture.
• Antibody generation and purification.
• Labelling and characterisation of antibodies and other constructs for in vivo imaging and drug delivery.
• Widefield and Confocal microscopy for ex vivo analysis.
• Optimising and performing a variety of assays including FACS, ELISA, western blotting, IHC, ICC and qPCR.
• Handling and processing of data and data presentation.

What we are looking for:

• BSc Degree in Biological Sciences or related field or equivalent vocational qualification required, MSc is desirable.
• Practical experience with in vivo work, including a personal home office licence (PIL AB+C).
• Practical experience in laboratory-based research with familiarity with some basic molecular techniques (FACS, ELISA, Immunohistochemistry, qPCR, Western blots).
• Experience with statistical analysis of data (PRISM) and presentation of data.

What we can offer you:

• A collaborative, supportive environment with leading scientists and clinicians.
• Be part of a high-impact, patient-focused research project.
• Access to state-of-the-art facilities and training in advanced cell biology techniques.
• Opportunities to contribute to publications and clinical translation.
• The opportunity to continue your career at a world-leading institution.
• Sector-leading salary and remuneration package (including 39 days off a year).

Further Information

This post is full-time and fixed term for 24 months, based at the Hammersmith Campus, London.

Candidates need to complete an online application.

Should you require any further details on the role please contact: Dr Ramzi Khamis (r.khamis@imperial.ac.uk)

About Imperial

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