Postdoctoral Researcher - UOD2361

We are recruiting an exceptional individual to join as a Postdoctoral Researcher in the laboratory of Prof Ian Ganley. This is a fixed-term appointment for 12 months.

The project will investigate the role of mitochondria in Parkinson’s disease. Previous research by the Ganley lab has contributed to the development of targeted therapies for PINK1-induced mitophagy which entered clinical trials for PD patients last year. However, recent advances have highlighted additional cellular pathways including proteostatic stress as modulators of mitophagy. The project will be aimed at uncovering entirely new understanding of mitochondrial stress that may lead to new concepts for therapeutic exploitation in PD. The successful candidate(s) will benefit from an interdisciplinary environment in the Ganley Lab in the MRC PPU in Dundee. The MRC unit also collaborates with a major pharmaceutical company that supports the Division of Signal Transduction Therapy that provides opportunities for interaction with industry and potential exploitation of new discoveries made in the lab. The Lab actively participates in Public Engagement, and successful candidates will be encouraged to be involved in public and patient involvement.

Overall, this position provides an exciting opportunity to be involved in world-class research projects and for the successful applicant to carve themselves a major international reputation. The successful candidate(s) will have an opportunity to be trained in a suite of state-of-the-art techniques during the project.

Your priorities will include:

• Cell and Molecular based mechanistic research studies
• Proteomic discovery platformsincluding PTM proteomics and organellar isolation workflows.
• Public and patient involvement and engagement presentations.
• Dissemination of protocols and data openly and through formal peer-reviewed publications.
• Advising and mentoring undergraduate and PhD students.

Candidate requirements:

• Have a PhD in Cell Biology, Biochemistry, Proteomics, Mouse Neuroscience, or related discipline with outstanding academic track record and a publication record in internationally recognised peerreviewed journals.
• Have a strong interest in autophagy research and how disruptions of these pathways are linked to human disease.
• Have a strong background in mouse neurobiology, biochemistry, cell biology proteomics and/or gene editing.
• Have a strong ability to work independently but with excellent ability to work in a team, and an open and collaborative approach to science.
• Highly organised, motivated and meticulous, with an ability to work independently and to drive a project forward robustly and at pace.
• Have excellent communication skills and knowledge of the English language are essential.
• Prior experience in mouse neurobiology or proteomics would be highly desirable.

For further information about this position please contact Prof Ian Ganley at i.ganley@dundee.ac.uk.

To find out more about MRC PPU please visit https://www.ppu.mrc.ac.uk/

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