Postdoc - Hill Lab

Location: The Francis Crick Institute, Midland Road, London

About us  

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. 

To learn more about the Crick, click here.

About the role 

The Research Group

The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease. Our work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. 

Click here to find out more about the Hill Lab 

What you will be doing 

We are looking for a highly motivated postdoc with proven research abilities and excellent publication record to work on a project that addresses how endoderm and mesoderm progenitors are specified in early zebrafish embryos through the interplay between Nodal and FGF signalling and cell cycle dynamics. 

The project will focus on determining the underlying mechanism of Erk mitotic erasure which we hypothesise is a widespread phenomenon as we have shown it not only occurs in zebrafish, but also in Drosophila embryos and human and mouse stem cells. We then aim to understand in more detail how it contributes to the endoderm switching and explore what other cellular processes are dependent on these variable windows of Erk inactivity. 

Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. 

Please see full job description here 

About you 

You will bring 

You will: 

• PhD in a relevant biological science, ideally in developmental biology*
• Good knowledge and experience of working with zebrafish as a developmental system*
• Technical expertise in zebrafish embryology, live imaging and image analysis*
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals*
• Strong evidence of data presentation at scientific meetings
• Strong organisational skills and thorough record-keeping
• Ability to work independently and also in a team
• Experience in signal transduction research (desirable)
• Experience cell cycle research (desirable) 

Minimum criteria* 

About Working at the Crick 

Our values  

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently. 
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. 
• We are collegial. We show respect for one another, work cooperatively and support the wider community. 

At the Crick, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. If you need assistance with your application, please contact karen.au@crick.ac.uk

To read more about our EDI approach, click here.   

What will you receive?  

We value our team members and are proud to offer an extensive range of benefits to support their well-being and development. You can find out more about what we offer here.

To apply for this role, please click on the 'Apply' button above.

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