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Research Assistant-Autophagy in Neurodegeneration

King's College London - Basic and Clinical Neuroscience

Location: London
Salary: £32,676 including London Weighting Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th September 2021
Closes: 26th September 2021
Job Ref: 031068

Campus: Denmark Hill, London

Contact: Maria Jimenez-Sanchez,

Job description 

We are seeking a highly motivated research assistant to explore the link between autophagy and inflammation in astrocytes in the context of Alzheimer’s disease. This one-year position is funded by Alzheimer’s Research UK to work in the laboratory of Maria Jimenez-Sanchez, in collaboration with the groups of Dr Wendy Noble and Dr Beatriz Gomez Perez-Nievas.

The successful candidate will be passionate, committed and with a keen interest in our research in astrocytes, autophagy and neurodegeneration. We are looking for someone with previous knowledge and experience in general biochemistry, cellular and molecular biology techniques. The role will require great flexibility and independency, and will include working on a project independently while also participating in a highly collaborative environment.

Experiments from this pilot project will expand our limited knowledge about autophagy function in glial cells and will investigate the importance of autophagy to modulate the inflammatory response in astrocytes. Research models to use will mainly include primary mouse astrocyte and neuron cultures. The project may also involve working with organotypic brain slice cultures, human astrocytes derived from iPSCs and human brain tissue.

This position would be suitable for a recent master student or a current research assistant, who have previous experience in the lab and who want to increase laboratory and research skills.

The lab is based at the Maurice Wohl Clinical Neuroscience Institute at the Institute of Psychiatry, Psychology and Neuroscience, in King’s College London, Denmark Hill Campus.

This post will be offered on an a fixed-term contract for 12 months

This is a full-time post - 100% full time equivalent

Key responsibilities

  • Develop and undertake research of high quality in line with the aims of the project to enable better understanding of the contribution of autophagy in astrocytes to Alzheimer’s disease.
  • The role will involve the development of a specific research project independently, as well as to collaborate in other ongoing projects in the lab.
  • Competency on cell culture and general biochemistry techniques is required
  • Techniques to use may include the preparation of primary mouse astrocyte and organotypic brain slice cultures, growth of astrocytes derived from human iPSCs, cell culture and genetic manipulation using DNA and siRNA transfection approaches, protein analysis by western blot and Elisa, and confocal and high content imaging.
  • Carry out meticulous collection, analysis and interpretation of data 
  • Maintain careful permanent records of all experimental work 
  • Contribute to publications arising from the project
  • Attend and as appropriate, present research findings and papers at internal and external academic meetings and external professional conferences
  • Work in a collaborative manner and engage with other members of the group and department
  • Contribute when requiring to training and supervision of junior staff
  • Be committed to their own personal career development
  • Undertake any other reasonable duties that may be relevant to the role outline.

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

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