Computational Biologist / Bioinformatician (MMR)

Health Data Insight

Contract: 24-month fixed term

Application is by: Covering letter and CV to

We know that you are an expert in your area, well-paid and part of a great team but are you really fulfilled in your job?  Can we tempt you to come and work with us on a project to help families at inherited risk of bowel cancer? The project is funded by a charitable grant from Bowel Cancer UK, and the work will help NHS clinical and molecular geneticists to give the best care to patients with variants in their mismatch repair (MMR) genes.

We are looking for a bioinformatician or computational biologist to join a small team at Health Data Insight CiC (, a social enterprise working on initiatives using big data in healthcare.  We are a social enterprise, because we don’t believe it is right to make profit from patient data that has been collected by the NHS.

Our expertise is in finding and joining up complex healthcare data and we use this to gain insight and an understanding of how care is delivered. We develop software tools to help present and visualise information in an accessible and stimulating way to patients and a range of users within the NHS, local government and charities.

This project will build a national hereditary cancer register for England to collect vital data on individuals at high risk of developing cancer because they have inherited mutations in cancer predisposition genes.  We use pseudonymisation at source to gather genetic testing data on breast cancer (BRCA) and mismatch repair (MMR) genes from molecular testing laboratories across the NHS. The incoming data vary widely in format and structure from each laboratory. Each set of source data therefore needs to be algorithmically parsed and transformed into a standardised structure before being linked to cancer registration records – from where analysis can take place.

The successful candidate will work with the lead architect within the National Cancer Registration and Analysis Service (NCRAS; part of Public Health England) to develop bespoke applications and pipelines to collect, process and analyse sensitive healthcare data.

You will need to be proficient in computational biology, bioinformatics, or a related field, and have excellent modelling skills and a strong knowledge of HGVS mutation nomenclature and variant reporting conventions. Experience of natural language processing would be an advantage. You will also need to contribute to the operational management of projects and ongoing development, defining and prioritising requirements, and bringing a technical perspective.

This project will transform the lives of people at a real risk of developing cancer early in life – we would like you to be part of it.

Application is by covering letter and CV by midnight, Sunday 1st July 2018, to

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South East England