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Research Fellow - Analysis of Stochastic Single Molecule Data

University of Southampton - Cancer Sciences

Location: Southampton
Salary: £30,395 to £37,345 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 28th May 2019
Closes: 27th June 2019
Job Ref: 1134719CM - R

Location: Southampton General Hospital
Full Time, Fixed Term (24 months)

Analysis of Stochastic Single Molecule data

Applications are invited for the research fellow role to carry out research on a joint project between Dr. Sumeetpal Singh at the Department of Engineering, University of Cambridge and Prof. Raimund J. Ober at the Centre for Cancer Immunology at the University of Southampton.

Single molecule microscopy is an important new methodology that promises to provide major new insights into biomedical processes. The data is, however, very challenging to analyze due to the low signal to noise characteristics and the low photon count imaging characteristics and the necessarily complex probabilistic description of the acquired data. As a result advanced statistical and computational methods need to be developed for the analysis of such data.

This project aims to employ recent computational innovations from Statistics and Engineering, such as Sequential Monte Carlo and Particle Markov Chain Monte Carlo methods, for calibrating Hidden Markov Models pertinent to Single Molecule studies. This will cover both continuous and discrete-time formulations. Both Likelihood and Bayesian techniques for model calibration will be investigated covering issues concerning model identifiability, model appropriateness, efficiency of estimators, optimal experimental design. Project outcomes will be packaged as a suite of efficient Monte Carlo computational methods for Single Molecule studies.

The candidate will have a very strong background in statistical and mathematical techniques with a Ph.D. in a relevant subject. A background in single molecule microscopy is not required, but an interest in the subject matter will be important.

The post will be with the Centre for Cancer Immunology at the Southampton General Hospital, a newly constructed research building that is the result of a significant fund-raising campaign. The Centre builds on a 40 year history of pioneering immunology and cancer research at Southampton. It is the first dedicated cancer immunology centre in the UK that brings the complete research pipeline under one roof: from pioneering discovery science to applied research and preclinical modelling and crucially onto first-in-human clinical trials and beyond. It is home to world-class research facilities, state-of-the-art scientific laboratories and a Clinical Trials Unit.

Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon successful completion of the PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.

The position is currently planned to be for a length of two years.
Candidates from the EU and outside the UK/EU are also encouraged to apply.
In addition to the salaries listed above, benefits such as membership in a pension scheme are also provided.

If you are interested in this role and would like to discuss it further please contact Prof. Raimund J. Ober at and Dr. Sumeetpal Singh at .

Application Procedure

You should submit your completed online application form at The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Ita Holmes (Recruitment Team) on +44 (0) 23 8059 9002. Please quote reference 1134719CM - R on all correspondence.

Interview Date: To be confirmed

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