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Staff Scientist Position - Structural and functional studies of protein complexes

European Molecular Biology Laboratory (EMBL)

Location: Hamburg - Germany
Salary: (Grade 8)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 4th July 2019
Closes: 8th August 2019
Job Ref: HH00172

About the team/job

The EMBL Hamburg Unit both provides and uses leading research infrastructure for applications in structural biology. A thematic focus shared between different research groups of the Unit is on addressing key questions in infection biology mechanistically.

The research group of Matthias Wilmanns has a long-standing record in structural biology on research themes of medical relevance. Our main research interest is on structures of large protein translocation systems and structural dynamics of giant muscle proteins. We additionally collaborate on specific research projects with several clinical groups with interests in tuberculosis, cancer and hereditary diseases. Most of our projects require integrative structural biology methods including X-ray crystallography, electron microscopy and complementary biophysical and biochemical approaches. The group shares expertise and research infrastructures with other EMBL research groups in Hamburg. 

Your role

You will lead and contribute to research projects of the Wilmanns group, specifically in the areas of protein expression (including eukaryotic hosts), purification, biochemical and biophysical characterization, as well as structural biology approaches. You will also contribute to grant applications, support of active grants, presentations of group activities at external meetings and training of young researchers in relevant methods and technologies.

You will also lead the molecular biology laboratory at S1/S2 safety standard that is shared with other research groups and in close cooperation with the Sample Preparation and Characterization (SPC) facility at the EMBL Hamburg Unit. In this task, the candidate will be supported by technical staff. 

You have

You should have a PhD in a relevant field and ideally two years of postdoctoral work that has resulted in significant peer reviewed publications. Working experience and theoretical knowledge in molecular biology, protein expression in eukaryotic hosts and purification, biochemistry and protein interaction assays are required. Project management experience, excellent communication skills and the ability to supervise and collaborate with other research teams are essential. Good knowledge of desktop software applications and fluency in English are mandatory. 

You might also have

Previous experience in structural biology approaches (X-ray crystallography, single particle microscopy), microbiology, as well as in vitro and in vivo functional assays will be advantageous. 

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits. Scientists at the EMBL Hamburg Unit benefit from cutting-edge technology to accommodate their research, with on-site synchrotron radiation beamlines operated by EMBL and opportunities for collaboration with colleagues from all six EMBL units.

What else do I need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

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