|Salary:||£27,511 to £32,817 per annum|
|Placed On:||15th November 2019|
|Closes:||16th December 2019|
Salary: £27,511 to £32,817 per annum, depending on skills and experience (minimum £30942 with relevant PhD).
The project title : Structure and inhibition of Agr quorum sensing proteins.
You will join a well-established MRC funded research group studying bacterial quorum sensing proteins. The project will explore the structure and biochemistry of the Agr system. In Staph. aureus, the agr quorum sensing system regulates virulence, intracellular survival and biofilm development and is conserved in other staphylococcal species as well as Listeria, Enterococcus and Clostridium. For each of these pathogens, the key agr components are an autoinducing peptide (AIP) signal molecule and a two component sensor regulator system. AIPs generated from an AgrD pro-peptide via AgrB are exported and subsequently sensed via a sensor kinase (AgrC) on neighbouring cells. Phosphorylated AgrC activates the response regulator, AgrA to auto-induce more AIP production and drive virulence factor expression directly or via, at least in staphylococci, the regulatory RNAIII effector. This project is a collaboration within the structural biology group (Jonas Emsley), synthetic chemistry (Weng Chan) and microbiology (Paul Williams group). The project is already well established in terms of recombinant purified proteins and complexes available for crystallisation.
We are looking for a highly motivated candidate with an interest in protein structure and macromolecular crystallography. You will have a PhD (or near completion) in protein crystallography. Experience in protein biochemistry, measure protein: ligand interactions protein expression/purification, protein complex isolation and protein crystallisations is highly desirable.
You will have excellent communication skills, which are evident from written reports and publications, as well as presentations and discussions. In addition, you will be an effective team member with a strong commitment to interdisciplinary research, in particular between molecular structure and function. Previous experience in protein complex structure determination is desirable.
This is a full time, fixed term position until 31 December 2020.
Informal enquiries may be addressed to Professor Jonas Emsley, email: firstname.lastname@example.org, tel 0115 951 8467092. Please note that applications sent directly to this email address will not be accepted.
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