|Salary:||Competitive with benefits, subject to skills and experience|
|Placed On:||2nd October 2020|
|Closes:||31st October 2020|
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term, 4 years
Pontus Skoglund's Ancient Genomics Lab at the Francis Crick Institute in London is looking for a postdoctoral fellow interested in developing computational methods for paleoproteomics to uncover new insights about the past. The lab (www.skoglundlab.org) is a dynamic team with backgrounds in computational evolutionary genomics and biochemistry, with a dedicated facility for retrieval of ancient biomolecules.
Ancient genome sequencing has revolutionized our understanding of the evolutionary history of modern humans and close relatives. However, in most environments, DNA retrieval may only extend up to a few thousand years ago. An emerging horizon comes from the fact that proteins degrade more slowly than DNA, and may thus allow evolutionary informative data to be obtained from deeper time and new environments. However, the number of evolutionarily informative variants in paleoproteomic data is much lower than genomes, and bioinformatic methods for paleoproteome reconstruction are in their infancy.
This is an opportunity to push a technological envelope to gain insights into the evolution of humans and other species of the Ice Age and beyond. The work will include improving and developing methods for bioinformatic retrieval, authentication, and reconstruction of ancient protein sequences from extinct populations, adapting population genetic and phylogenetic approaches, and applying the methods to data from fossils. The project will be done in close collaboration with Bram Snijders, head of the Mass Spectrometry Proteomics STP at the Crick Institute, and other collaborators at the Crick and internationally.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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