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Senior Research Associate

University of Bristol - Faculty of Health Sciences - Bristol Medical School

Location: Bristol
Salary: £38,587 to £43,434 per annum
Hours: Full Time
Contract Type: Permanent
Placed On: 30th September 2021
Closes: 28th October 2021
Job Ref: ACAD105613

The role

We are seeking a talented epidemiologist/biostatistician, with a relevant PhD/MSc or equivalent experience. As the successful candidate you will have a keen interest in biomedical research and a systematic and thorough approach to their work. You will work within a recently funded Scar-Free Foundation Programme (entitled “Using large cohort studies to identify scar-associated genetic variants for mechanistic testing in mouse and zebrafish models of wound healing”) and within the Medical Research Council Integrative Epidemiology Unit at the University of Bristol (MRC-IEU) and Population Health Sciences in the Bristol Medical School. The key component of this work will be analysis of the relationship between human germline genetic variation and population level measures of scarring and wound repair. This will include overt examples of wounding (e.g. skin scar measures) and also clinical diseases and outcomes where wounding and repair are important factors (e.g. pulmonary fibrosis).

What will you be doing?

The next steps for this work and involve finding additional gene targets for scarring to test in mouse and zebrafish models. Specifically, this will involve;

  • a) extending analysis of BCG scarring with a larger sample size in the Bristol cohort and inclusion of an additional birth cohort
  • b) undertaking novel genetic analysis of caesarean section scar size as another measure of scarring tendency
  • c) working in a collaboration with other groups to identify genetic contributions to clinical endpoints with relevance to scarring, including fibrosis
  • d) bioinformatic annotation of genetic association results to prioritize the most interesting targets for wet lab follow-up.

 The successful candidate will be embedded within a close-knit and enthusiastic team consisting of the PI, several post-docs and postgraduate students and technicians. The candidate will liaise closely with the PI and their colleagues working on  mechanistic testing in mouse and zebrafish models of wound healing in the lab of Professor Paul Martin, Bristol (http://www.bris.ac.uk/biochemistry/people/paul-b-martin/index.html). The successful candidate will need to oversee project progress, taking the initiative in the majority of day-to-day decisions about experimental details, troubleshooting and budgeting. You will be responsible for:

  • Thorough documentation and version control of all data resources, analyses and results
  • Ensuring databases remain up to date and accessible to those who need access and compliant with research ethics, governance and good practice.
  • Actively contribute to University, MRC IEU and ALSPAC administrative meetings as appropriate.
  • Carry out responsibilities with regard to the University’s equal opportunities and health & safety policies as appropriate.

You should apply if

You should apply if you are able to attend to these responsibilities:

  • Developing and writing detailed statistical analysis plans.
  • Curation and documentation of data generated in ALSPAC, working closely with the ALSPAC data team.
  • Preparing data for analyses, including applying any relevant quality control checks.
  • Undertaking genetic association and bioinformatic analyses
  • Contributing to research publications and conference presentations.
  • Keeping up to date with scientific and professional issues consistent with their role.
  • Ensuring that all work adheres to research governance, data protection and confidentiality protocols.

Additional information

Contract type: Open ended with funding for 3 years initially

Work pattern: Full time / 1FTE

Grade: J / Pathway 2

Shift pattern: 35 hours per week

For informal enquiries please contact Professor Nic Timpson (n.j.timpson@bristol.ac.uk)

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

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