|Salary:||£38,826 to £43,239 per annum including London Weighting Allowance|
|Placed On:||5th October 2021|
|Closes:||31st October 2021|
This post will be offered on a fixed-term contract until 31 March 2025
Muscle Activity and Growth: from Developmental Genetics to the Human Population. The PDRAs will work collaboratively in the group of Professor Simon M. Hughes in the multidisciplinary Randall Centre to study:
Post 1) The role of physical force in the growth of skeletal muscle through a novel force-sensing system.
Post 2) The role of muscle stem cell heterogeneity in growth and repair of skeletal muscle.
The successful candidates will have deep understanding of experimental design and analysis in modern biomolecular and genetic research, and will work with zebrafish.
Post 3) The genetic and environmental causes of sarcopenia, ageing-related muscle wasting. This project, in collaboration with genetic epidemiologist and health data scientist Dr Nick Dand (KCL), will employ UK Biobank data to analyse the genetics and epidemiology of sarcopenia.
The PDRAs will join our MRC-funded team focused on understanding the molecular and cellular mechanisms of muscle growth, maintenance and repair. We want to know how exercise, nutrition and time of day interact with genetic predisposition to determine individual trajectory by generating hypotheses from human data and testing them in model systems. Experience with molecular genetics, timelapse confocal microscopy, zebrafish, equipment construction, physiology, GWAS, data analysis in R and muscle may all be advantageous.
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