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Post Doctoral Training Fellow - Patient Derived Models Team: Professor Cathrin Brisken

The Institute of Cancer Research - Breast Cancer Research - In Vivo & Patient Models

Location: London
Salary: £38,607 to £41,718 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 6th October 2021
Closes: 31st October 2021
Job Ref: 1414

Closing Date: 31/10/2021, 23:55

Length of Contract: 3 years

Hours per Week: 35

The ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

Vacancy Description  

Oestrogen Receptor positive (ER+) breast cancer is the most prevalent type of breast cancer. Despite the availability of hormonal therapies for patients, this type of cancer frequently recurs ultimately killing patients. There is an unmet clinical need to identify new preventative approaches to recurrence and for drugs that can be used when patients relapse with endocrine therapy-resistant disease.

The Patient Derived Models Team headed by Prof. Cathrin Brisken focuses on developing patient derived xenograft (PDX) models for preclinical studies and personalized medicine. Research on estrogen receptor positive (ER+) breast cancer has long been hampered by the lack of adequate in vivo models for the disease. Her team has overcome this hurdle and demonstrated that grafting to the correct microenvironment is critical for ER+ tumor cells to retain their biological characteristics  [Sflomos et al Cancer Cell 2016, Fiche et al J Pathol 2018, Sflomos et al EMBO Mol Med 2021, Shamseddin et al EMBO Mol Med 2021] opening new opportunities for basic and translational research. The Patient Derived Models Team provides expertise and support for the Centre to further the use of clinically relevant models in research.

A Postdoctoral Training Fellow position is available to advance novel PDX models for preclinical studies, translational projects and co-clinical trails. The successful candidate will develop a pharmacological work flow, predictive biomarker discovery and contribute to generating pre-clinical information that can inform the design of clinical trials.

We are seeking a highly motivated candidate who enjoys working in a multidisciplinary environment as part of a team. You must possess a PhD in pharmacology, biochemistry, biology, or other associated subjects and have a strong track record in biomedical research. Experience in pharmacokinetics and dynamics, mass spectrometry, molecular biology, statistics, and in working with in vivo cancer models is highly desirable.

The candidate will benefit from close interactions with the other teams within the Centre (https://www.icr.ac.uk/our-research/research-divisions/division-of-breast-cancer-research) and the ICR at large and interact with industrial partners.

This is a fixed term appointment for 3 years in the first instance.  Appointments will be made in the salary range £38,607 p.a. to £41,718 p.a. inclusive. Starting salary will be based on previous postdoctoral experience (£32,844 p.a. starting salary  for pre viva applicants who are still awaiting PhD Award after thesis submission).

To apply please submit an application on the ICR Careers site, attaching your CV with the supporting statement addressing with specific examples where you meet the person specification, a brief description of your relevant experience and including  the names and addresses of at least two referees. 

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