|Placed On:||15th October 2021|
|Closes:||30th November 2021|
Contract: Fixed Term (until May 2023), Full time
Salary: Circa £45,000
Altered metabolism is one of the cancer hallmarks and offers promising opportunities for designing new therapies. We are using mouse models and metabolomics approaches to evaluate the requirement of metabolic pathways for tumours carrying specific genetic lesions. The complexity of metabolic interactions between a tumour and the rest of the body, flexibility of metabolism and inter and intra tumour heterogeneity present challenges that require the development of new approaches in order to understand how to target the altered metabolism of tumours efficiently and specifically.
Our lab uses various metabolomics approaches to evaluate the activity of metabolic pathways in vivo including mass spectrometry imaging. Ultimately we are aiming to determine how metabolic changes are aligned with genetic profiles of tumours in time and space and how these interactions determine tumours’ metabolic vulnerabilities. The post holder will be a part of the team of researchers in Mariia Yuneva’s lab and will also interact with researchers from National Physical Laboratory and Imperial college London.
The successful candidate is likely to be an energetic, focused, and productive individual with a desire to work in a congenial, dynamic, and collaborative research environment. Good organisational, analytical, and communication skills are essential.
Specific objectives will include, but not be limited to:
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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