|Salary:||£38,826 including London Weighting Allowance|
|Placed On:||26th October 2021|
|Closes:||30th November 2021|
Denmark Hill, London
We are seeking a postdoctoral research associate position to work on an MRC-funded project to explore the role of molecular chaperones in astrocytes in the context of Alzheimer’s disease. This a 2-year position to join the laboratory of Maria Jimenez-Sanchez.
The successful candidate will be a highly motivated scientist who is passionate about science and has a background in neurodegeneration and/or proteostasis research. The postdoctoral researcher will lead a project to explore the cellular and molecular mechanisms by which extracellular chaperones exert protective functions in Alzheimer’s disease. We are looking for someone with cell biology, biochemistry and imaging expertise in neuronal biology in the context of neurodegeneration. Research models to use will include primary neuron and glial cultures and long term organotypic brain slice cultures. We will use AAVs, recombinant proteins and/or siRNA/DNA transfection to modulate levels of relevant proteins in these models to investigate the impact of chaperones in Alzheimer’s disease pathology and their mechanisms, including tau pathology, synaptic and neuronal dysfunction. The project may also involve working with human post-mortem Alzheimer’s disease brain samples. We expect you to have a large degree of independence and will make major practical and intellectual contributions to the project. Time management skills and the ability to work with others as well as to train and supervise students in the lab are required.
The lab is based at the Maurice Wohl Clinical Neuroscience Institute at the Institute of Psychiatry, Psychology and Neuroscience, in King’s College London, Denmark Hill Campus.
This post will be offered on an a fixed-term contract for 24 months.
This is a full-time post - 100% full time equivalent.
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
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