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Research Associate (Fixed Term)

University of Cambridge - Cancer Research UK Cambridge Institute

The Hannon laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is seeking to hire a  Post-doctoral Research Associate to join a team of scientists studying the spatial architecture of triple-negative breast cancer (TNBC) and its response to treatment.

With support from a CRUK Grand Challenge grant, we have built very substantial capabilities for carrying out spatial molecular profiling of RNA and proteins in 2- and 3-D.  We were recently funded as part of the Wellcome Trust LEAP Delta Tissue Program to form a consortium to profile the 'tissue state' of TNBC prior to and after neo-adjuvant chemotherapy in responders and non-responders with the goal of creating an algorithm to predict tissue end state from its initial state.  The PDRA in this role will work and interact with an interdisciplinary team which includes molecular cancer biologists, immunologists, clinical researchers, and computational scientists in Cambridge, London, and Vancouver. The team comprises co-leads Jean Abraham and John Marioni and co-I's Jasmin Fischer, Menna Clatworthy, Walid Khaled, and Sam Aparicio. 

The role holder will undertake sample preparation, multiparametric analysis of dissagregated single cells, and spatial profiling of RNA and proteins.  Though the project as a whole is a team effort the PDRA will take ownership of aspects of data generation and will be expected to contribute intellectually to all aspects of the project, including troubleshooting of sample preparation pipelines, library generation, data analysis and interpretation, and evaluation of the computational models. The ability to consistently carry out complex molecular biology protocols is essential, and familiarity with single cell workflows would be highly desirable.  The successful candidate will be creative and bring their original contribution to the research project, show self-initiative as well as the ability to effectively manage time and priorities.

The successful candidate will have completed or be near completing a PhD in a relevant discipline (Biology, Biochemistry, Natural Sciences). Some post-doctoral research experience would be beneficial but is not a requirement.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

To apply online for this vacancy and to view further information about the role, please visit :

Closing Date: 9th December 2021.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please quote reference SW28962 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Location: Cambridge
Salary: £33,309 to £40,927
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 12th November 2021
Closes: 9th December 2021
Job Ref: SW28962
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