Postdoctoral Research Fellow

Closing date: 5pm on 03/06/2022

We have a postdoctoral researcher opportunity available in the laboratory of Dr. Tom Deegan at the MRC Human Genetics Unit in Edinburgh.

The Opportunity:

We seek an outstanding candidate to join the group of Dr. Tom Deegan, within a programme aimed at understanding the molecular mechanisms and regulation of eukaryotic DNA replication. We have developed biochemically reconstituted systems to interrogate the ill-defined termination phase of DNA replication at the molecular level (Deegan et al, Mol. Cell., 2019; Deegan et al, eLife, 2020), and have recently described a mechanism for eukaryotic replisome disassembly (Jenkyn-Bedford et al., Nature, 2021). A number of projects are now available, using biochemical reconstitution with purified yeast and human proteins, cryo-EM, and mammalian cell models to investigate molecular mechanisms of DNA replication termination, and how this process is subverted under the types of DNA replication stress that are characteristic of human cancer. Our group is part of the MRC Human Genetics Unit, a world class centre, which provides a highly collaborative and multi-disciplinary environment within which to study eukaryotic chromosome biology.

Your skills and attributes for success:

•    Strong interest in DNA replication and/or chromosome biology and/or genome integrity
•    Experience in protein and nucleic acid biochemistry or studies of DNA replication in mammalian cells
•    Ph.D. (or near completion) in a relevant science subject
•    Proven track record of publication in peer-reviewed journals
•    Strong communication and collaboration skills

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