Postdoctoral Researcher in Genome Stability

Job Details (corehr.com)

About the role

Applications are invited from enthusiastic, motivated individuals for a CRUK-funded Postdoctoral Researcher position for Professor Madalena Tarsounas’s Group, within the Department of Oncology. You will join an exciting research programme which combines cell/molecular biology and microscopy approaches with high-throughput technologies and bioinformatics to understand how BRCA1 and BRCA2 facilitate DNA replication and how this, in turn, impacts chromosome segregation during mitosis. We have recently mapped genome-wide the sites where mitotic DNA synthesis occurs in BRCA1/2-deficient cells (Groelly et al*, Molecular Cell,* in press), using state-of-the-art technologies (e.g. MiDAS-seq, high-content microscopy) and found that they co-localise with sites of R-loop formation. We now aim to investigate the roles of ATR/ATM kinases, as well as of MUS81 (Lai et al. Nat. Communications 2017) and other nucleases in regulating this process.

In this role, you will work as part of a team of postdoctoral researchers, collaborating with researchers from across the University of Oxford’s various technology platforms. You will be responsible for developing and testing your own hypotheses, generating high-quality and reproducible data, participate in dissemination activities and aid in manuscript preparation. You will also be required to provide guidance/supervision to other members of the research group, including PhD/MRes students.

You will hold (or be very close to completing) a DPhil/PhD in Oncology, Biology or other related discipline, together with relevant experience.  Experience in DNA damage signalling and repair is essential, together with computer literacy and a good record of publication(s) in internationally recognised journals. Experience with analysis of ChIP-seq and/or EdU-seq data would be advantageous.

The position is based in the Department of Oncology, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ and is offered on a full-time, fixed-term basis for three years.

The post holder should ideally be in place by 01 October 2022.

Applicants should read the job description before completing their application. You will be required to upload a supporting statement, setting out how you meet the selection criteria, a CV, including a statement of career interests, and the contact details of two referees as part of your online application.

Informal enquiries can be directed to Professor Madalena Tarsounas at madalena.tarsounas@oncology.ox.ac.uk 

Only applications received by 12pm BST on Friday 26 August 2022 will be considered.

Interviews are expected to take place on Friday 09 September 2022. Applicants should be available to attend on this date.

Committed to equality and valuing diversity

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