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Postdoctoral Research Associate

University of York - Biology

Location: York
Salary: £34,308 to £42,155 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 27th September 2022
Closes: 18th October 2022
Job Ref: 11321

Role Description

Project and Departments

The Departments of Biology and Physics are collaborating within the University of York Biophysical Sciences Interdisciplinary Network (BPSInet) to support a major UKRI interdisciplinary project. The consortium is recruiting a highly motivated postdoctoral research associate (PDRA) to join an interdisciplinary team on a project exploring the liquid-liquid phase separation (LLPS) that underlies efficient CO2 fixation in algae.Algae are responsible for approximately 30% of global carbon fixation and have huge potential for providing biotechnological solutions for CO2 capture and boosting crop yields. Their ecological success is driven through their high photosynthetic capacity. To "turbocharge" photosynthesis they condense the primary CO2 fixing enzyme Rubisco into a LLPS organelle called the pyrenoid. This project will work on understanding pyrenoid structure and function in diverse algae to identify the underlying physics of the pyrenoid to help guide ongoing engineering solutions for improved CO2 fixation.

Roles

Within the project, you will be part of an interdisciplinary team conducting research to understand the physics of pyrenoid assembly and function. You will be integrated into the York Physics of Life network and interact closely with the three other PDRAs working on the project. You will have a core research role, with guidance and supervision from senior colleagues. In addition, you will assist in the identification and development of potential areas of research, the development of proposals for independent or collaborative research projects, and the writing of research papers for publication. The available position is in algal cell and molecular biology (Mackinder Lab, Biology). You will work on the molecular and cell biology of diverse algae. Work will involve in vivo and in vitro characterisation of pyrenoid proteins and pyrenoid dynamics. In vivo work will include protein localisation, live-cell microscopy, gene editing and algal physiology. In vitro aspects will include recombinant expression and protein purification to enable pyrenoid reconstitution via LLPS. In addition, biochemistry approaches will be used to identify protein interactors and protein-protein binding affinities.

Skills, Experience & Qualification needed

You will have an interest in the subject matter of the project and possess a relevant PhD in the field of molecular biology, cell biology, biochemistry or a related subject. You will have experience in a range of relevant practical and data analysis techniques. You will have attention to detail, a commitment to performing high quality research and a collaborative ethos with a willingness to work positively and proactively with colleagues in other departments and institutions. You will have the ability to efficiently meet deadlines, to disseminate research results professionally in written and oral form and have the initiative to plan research programmes. Excellent communication skills are essential and you should be keen to develop project/team leadership skills

Interview date: To be decided

For informal enquiries: please contact Luke Mackinder (luke.mackinder@york.ac.uk).

The University strives to be diverse and inclusive – a place where we can ALL be ourselves.

We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.

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