Postdoctoral Research Assistant in Cardiovascular Biology & Metabolism

*This is a re-advertisement, previous applicants need not apply.

We are seeking a highly motivated Postdoctoral Research Assistant to come and work under the overall supervision of Prof. Keith Channon, in the Division of Cardiovascular Medicine’s laboratories at the Wellcome Centre for Human Genetics (www.well.ox.ac.uk), working closely with the laboratory of Prof. Chris O’Callaghan in the same building. The Wellcome Centre for Human Genetics is a world class molecular medicine research facility located on the University of Oxford’s Old Road campus, co-located with major research institutes, facilities and hospitals. This facility provides an outstanding work environment, with excellent core services and opportunities for interactions with cardiovascular, molecular and developmental biologists & geneticists.

You will work in a team with students, research assistants and other postdoctoral research assistants, investigating new roles for redox signalling in cardiovascular disease pathogenesis. You will take the lead on a project investigating the role of a novel cardiovascular gene which has been identified from our studies of redox signalling related to nitric oxide synthase and its cofactor, tetrahydrobiopterin. In particular, you will investigate how changes in the gene impact on vascular function, and metabolism in bone-marrow derived cells, via transcriptional and epigenetic mechanisms. You will be responsible for leading a major part of the work supported by a newly-awarded 5-year British Heart Foundation Programme Grant. Some of the duties will include the use of tissues derived from novel targeted genetic mouse models, analysis of cellular metabolism and bioenergetics, and transcriptional/chromatin regulation. 

You will be required to hold (or be near to completion of) a PhD or DPhil in a relevant discipline (such as Biochemistry, Pharmacology, Molecular and Cell Biology or Natural Sciences), have proven recent experience in the analysis of redox signalling, metabolism and gene expression in myeloid cells, or other cardiovascular cells, relevant to cardiovascular disease pathogenesis. Proven experience in the field of cardiac metabolism and experience of working with experiment animals models would be desirable.

This is a full time appointment on a fixed term contract until 31st July 2027 funded by The British Heart Foundation and you will be based at the Wellcome Centre for Human Genetics, Old Road Campus, Roosevelt Drive, Oxford.

Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post. 

Only applications received before 12.00 midday on 20 February 2023 can be considered. Interviews are scheduled to place at the beginning of March. 

The University is an Equal Opportunity Employer

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