Wellcome Sanger Institute

Computational Postdoctoral Fellow - Single-cell Genomics in the Haniffa Group

Wellcome Sanger Institute

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.

About the role:

The Cellular Genetics Programme is seeking a Postdoctoral Fellow (PDF) to support the Haniffa Group for a 3 year fixed term contract. The Programme is focused on cell-atlasing and aims to map tissues by combining single cell transcriptomics, spatial genomics and computational methodologies to build full-transcriptome three dimensional (3D) models of cells in their tissue context, with the long-term ambition of building a 3D whole-body atlas at single cell resolution.

About us:

Muzlifah Haniffa is a dermatologist pioneering the applications of single cell genomics technologies to understand human development, tissue homeostasis, immunity and disease pathogenesis. A major research goal of her laboratory is to decode the development and functional maturation of the human immune system and whole embryo development. The Haniffa Group's research within the Cellular Genetics Programme applies disruptive cutting-edge single cell and spatial genomics techniques to study human development and adult healthy and diseased tissues.

About the Role:

You will be responsible for analysing large single-cell genomics including spatial genomics datasets relating to the Human Cell Atlas research to deliver key insights. You will work collaboratively with wet lab biologists and be involved in generating the data, other researchers including bioinformaticians in the Haniffa group, Cellular Genetics programme including IDS team, EBI and international collaborators.

About you:

You understand key concepts in genomics, biology, immunology, data processing and data analysis. You will ideally have experience in the management and analysis of single cell genomics data sets, using or developing statistical/machine-learning methods for the analysis of large-scale data sets. You work effectively within a team and independently. You also organise workload and communicate adequately.

As a PDF in the Cellular Genetics Programme, you will be joining a collaborative and cutting-edge environment. The Programme encourages everyone to network and to showcase their research, including at our weekly seminar series. In addition to support from the Sanger core areas of Scientific Operations, Management Operations and ICT, within the Programme the Cellular Genetics Operations teams provide comprehensive multidisciplinary support to help with everything from processing samples, delivering analysis pipelines, to assistance with fellowship applications. The Sanger Institute also supports PDFs by offering various training opportunities, chances to network, and has a PDF committee in place to ensure our PDFs are supported throughout their posts. For more information about being a Postdoctoral Fellow - please visit: https://youtu.be/1-vxm2nBmFA

Essential Skills:

Technical Skills:

  • A PhD in biomedical sciences e.g. immunology, computational biology, bioinformatics, biostatistics or related scientific discipline
  • Understanding and experience in the fields of immunology, genomics, data processing and high- throughput data analysis

  • Extensive experience in a research environment with an established track record of productivity

  • Proficiency in one or more scripting languages (C/C++, R, python)

 Competencies and Behaviours:

  • Excellent communication and organisational skills.

  • Proven independent working style, technical problem solving, data analysis and generation of novel ideas

  • Motivation and ambition to make a personal contribution to GRL research

  • Proven ability to work effectively within a team

  • Ability to work multi-task and organise own workload

  • Good attention to detail and record keeping

  • Demonstrates inclusivity and respect for all

Other Information:

Salary per annum: £35,707-£44,712

Application Process:

Please apply with your CV and a Cover letter outlining how you meet the skills set out above.

Closing Date: 9th February 2023

Working at Wellcome Sanger:

Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.