Research Fellow

Fixed Term contract up to 5 years

Research Fellow

Organoid models are “mini avatars” of cancer whereby we can grow faithful 3D models of disease by appropriately manipulating the stem cell microenvironment using growth factors, in a 3D matrix. They provide a high-fidelity model of cancer, but can also be combined with other cells, such as immune cells, fibroblasts, and endothelial cells for a complete model of cancer.

The Surgical Research Group (led by Professor Andrew Beggs) has been funded by the Medical Research Council and AstraZeneca to carry out various projects researching the use of organoids in cancer therapy and the response of cancer to treatment. We will be expanding our organoid derivation labs with this funding. We operate in dedicated high spec tissue culture space with access to high content microscopy, drug screening and irradiation.

We are looking for scientists as excited by the potential of this technology as we are, and who are wanting to work as part of a collaborative, multi-disciplinary team of scientists and clinicians to use organoid models of cancer to improve patient care and make new scientific discoveries.

Main Duties:

• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Analyse and interpret data
• Apply knowledge in a way which develops new intellectual understanding
• Disseminate research findings for publication, research seminars etc
• Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
• Contribute to developing new models, techniques, and methods

Person Specification

• First degree in area of specialism and normally, a PhD (or near to completion) relevant to research area or equivalent qualifications
• Candidates with experience in organoid culture preferred, but candidates with extensive experience of 2D cell culture will also be considered
• Ideally, experience of PBMC culture and derivation of immune cell subpopulations, and experience in immunology experiments especially desirable.
• Experience of flow cytometry will be an advantage
• Experience of CRISPR/Cas9 methodologies
• High level analytical capability
• Ability to communicate complex information clearly

For further information please contact Professor Andrew Beggs A.Beggs@BHAM.AC.UK

To download the full job description and details of this position and submit an electronic application online please click on the Apply Online button above or visit our careers website.

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