Post Doctoral Research Assistant

Full Time

Fixed-term until 30th September 2023

Grade 7 £35,308 - £43,155

We are recruiting for an exceptional individual to join us as a Postdoctoral Research Assistant within the Division of Cancer Research to study the role of RNA binding proteins in sarcoma cells. This position is fixed-term until 30th September 2023 but may be extended with onward funding being sought.

Post-doctoral researcher position available in the laboratory of Professor Kevin Hiom to study the role of RNA binding proteins in sarcoma cells. This exciting project builds on our recent findings that perturbations in mRNA processing with the generation of replication stress and impaired double strand break repair. We will use molecular and cellular biology as well as genetic and whole genome approaches to determine the key interactions of RNA splicing factors and mRNA processing proteins that might be targeted for the treatment of Ewing sarcoma patients. This is initially a one-year funded project with the potential for onward funding by Cancer Research UK/ SU2C. The position will also be supported by the appointment of a technician. The successful candidate can start as soon as possible.

The Hiom lab is in the state-of-the-art Jacqui Wood Cancer Centre at the University of Dundee, where there is a vibrant genome stability community. Dundee offers a great quality of life with good transport connections, coupled with a very reasonable cost of living.

Your priorities will include:

• To carry out high quality lab-based research, working independently but contributing to the work and well- being of the group.
• Work under the guidance of Professor Kevin Hiom but assume responsibility for leading and driving the project forward.
• Undertake a variety of cell biology and molecular biology techniques, including preparation of genomic sequencing libraries.
• Continually update knowledge by frequent reading of the literature to keep pace with technical developments and progress on the field.
• Use initiative and creativity to problem solve difficulties, learn new techniques and identify new research areas.

Who we’re looking for:

• Use molecular biology to examine the localization and interactions of DHX9 and BRCA1.
• Use cellular and biochemical approaches including immunoprecipitation and high-resolution imaging to determine the role of RNA processing proteins in Ewing sarcoma.
• Work with cell lines derived from sarcoma patients and develop reporter cell lines in tissue culture for analysis of protein-protein interactions.
• Examine the efficacy of a potential DHX9 inhibitor

Appointment as a Postdoctoral Research Assistant on Grade 7 salary scale is dependent on candidate having a PhD, or may be considered on Training Grade 7 if you expect an award of a PhD.

The University of Dundee is a signatory of the Researcher Development Concordat and is committed to enhancing the research environment and culture. Engagement and support of activities which assist the researcher development agenda at the University is therefore essential.

Informal enquiries should be directed to Professor Kevin Hiom at k.hiom@dundee.ac.uk

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

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