|Salary:||£35,308 to £52,841|
|Placed On:||27th March 2023|
|Closes:||23rd April 2023|
The Miller lab seeks multiple post-doctoral fellows to implement a new Wellcome Discovery Award to study the conserved cellular machinery that mediates the first step of protein secretion, export from the endoplasmic reticulum. We aim to understand how cells maintain selectivity when handling a vast diversity of protein sequence and structure. Specifically, we will use genetic and biochemical approaches to dissect the molecular mechanisms by which cargo proteins are selectively captured into nascent vesicles. We then aim to leverage redundancy in this step to specifically abrogate a subset of interactions using small molecules, thereby inhibiting secretion of a subset of proteins. The project uses a blend of mechanistic approaches that dissect pro tein-protein interactions for export receptors, complemented by cell-based approaches to reveal the spectrum of proteins that engage these machineries in diverse cell types, and small molecule screens for modulators of these interactions. We are therefore recruiting multiple post-doctoral fellows with relevant expertise.
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
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Who we’re looking for:
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.
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