Senior Bioinformatician

Location: The Francis Crick Institute, Midland Road, London

Short summary

The Research Group

The collaborative labs comprise developmental and cell biologists interested in understanding the development and evolution of the vertebrate nervous system. Its organisation is initiated by secreted molecules forming extracellular gradients that regulate the expression of transcription factors. These control the identity and proliferation of neural progenitors thereby governing pattern formation and tissue growth.

Project summary

This position is to work on an exciting collaborative programme: the Human Developmental Biology Initiative (HDBI), funded by Wellcome. The overarching goal of the collaboration is to develop a set of experimental and computational methods for studies in human embryonic and foetal tissues by focusing on generating foundational data on cell lineage in human development.

Essential

• PhD or in the final stages of PhD submission in computational biology
• Expert-level programming skills in R or python or another language relevant to the role
• Good knowledge and experience of computational analysis of transcriptomic and/or genomic data.
• Experience of computational analysis of large datasets using R, Python or other appropriate language

Key Responsibilities

You will develop computational analyses of single cell transcriptomic and genomic data and drive data interpretation and design for validation. In collaboration with others working on the project, you will be responsible for the biological interpretation of integrated single cell datasets, this will involve working closely with experimental scientists. Together, you will develop follow-up projects for further validation and analysis. This will involve working with data collected from post implantation human embryos as well as models of development including in vitro human models and in vivo data from other vertebrates. You will also collaborate closely with other computational and experimental scientists working on other parts of the HDBI.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications 17.04.2023
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

Advert information