Senior Clinical Research Fellow in Motor Neuron Disease Live

University of Oxford - Nuffield Department of Clinical Neurosciences (NDCN)

Location:	Oxford
Salary:	£88,364 to £119,113 pro rata
Hours:	Part Time
Contract Type:	Fixed-Term/Contract

Placed On:	29th March 2023
Closes:	12th April 2023
Job Ref:	163945

The Nuffield Department of Clinical Neurosciences seeks an enthusiastic Senior Clinical Research Fellow, with expertise in Clinical Genetics, who is looking for the opportunity to develop their independent research career in Motor Neurone Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS, and the related disorder frontotemporal dementia, FTD) research, through their engagement with an established internationally-leading programme of neuroscience research, led by Professor Kevin Talbot, Professor Martin Turner and Dr Alexander Thompson.

Specifically, the broad aims of this programme of research will be to:

Determine the penetrance of MND gene pathogenic variants in the setting of both familial and apparently sporadic disease and also at population level.
Identify genetic factors that contribute to and protect against MND gene penetrance and quantifying their relative effects on risk.
Develop a personalised algorithm for calculating MND risk in unaffected relatives by combining genomic polygenic risk stratification with family history data.

The successful candidate will hold a relevant Ph.D./D.Phil. with post-qualification research experience, have demonstrable experience in the genetic analysis of motor neurone disease, and have working knowledge of statistical programs relevant to basic research. They will also have experience with the processing of human biosamples for DNA/RNA extraction and experience with molecular biology laboratory techniques i.e PCR.

Demonstrable expertise in clinical genetics, experience of research in neurodegeneration and experience of making grant applications is desirable.

Applicants are strongly advised to address each of the criteria in the job description when applying, rather than providing a generic statement of their experience and skills.

The post is part time (0.4 FTE), fixed term, until 31st March 2025.

Only applications received before 12:00 midday on 12th April 2023 will be considered.

Interviews will be held as soon as possible thereafter.

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