|8th November 2023
|7th January 2024
Much remains to be discovered about the dynamic regulation and principles underlying development, especially regarding the emergence and establishment of the body plan of the embryo. The Developmental Models Laboratory (Moris lab) aims to explore these themes using cutting-edge in vitro model systems. In particular, the group uses 3D gastruloids to model the coordinated emergence of multilineage tissues, axially organised in a spatiotemporal manner. Our work explores a range of questions, including the role of signalling in coordinating fate decisions in 3D, interactions between tissue types during early embryogenesis, and the specification and maturation of primordial germ cells (PGCs). In the future, our findings may provide a basis with which to better understand infertility, congenital abnormalities, and pregnancy loss through the establishment of disease models, alongside a better understanding of the regulatory logic of mammalian development more broadly
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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