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Institute of Developmental & Regenerative Medicine Postdoctoral Research Scientist and Junior Research Fellowship (JRF): Determining the Role of Autoimmunity During Heart Failure

Jesus College, Oxford – Institute of Developmental & Regenerative Medicine

The salary is on points 29-31 of the national pay spine, starting with point 29 (currently £36,024 per annum). Free meals in College, USS pension, research allowance of £1,000 per annum, are also offered. 

Applications are invited for a Postdoctoral Research Scientist to work with Professor Paul Riley on a collaborative project with Professor Georg Holländer within the Institute of Developmental & Regenerative Medicine investigating the role of autoimmunity during heart failure and how release of cardiac proteins after a heart attack can lead to loss of tolerance, production of autoactivated T-cells and anti-heart antibodies in the draining lymph nodes, which prolong cardiac injury after the initial insult and accelerate the progression to heart failure. Experiments will include use of transgenic mouse models to manipulate antigen expression in the developing thymus to re-educate T-cells in the context of heart injury to alter disease prognosis.

Responsibilities will include working with resident bioinformaticians and existing omics datasets to identify when and how cardiac proteins may escape recognition in the thymus; a detailed profiling of autoimmunity in mouse hearts and associated lymph nodes to determine antibody presence against specific cardiac proteins; induction of tolerance by genetic engineering of thymic epithelial cells to express specific cardiac antigens and use of drugs to inhibit egress of autoactivated T-cells as a parallel strategy to prevent re-circulation and additional damage. The successful applicant will carry out histological, cell biology and gene/protein expression studies to phenotype mouse disease and transgenic models. They will be required to use specialist scientific equipment in a laboratory environment, and to contribute to other on-going research projects within the laboratory, in accordance with experience and grade. In addition, they will teach experimental techniques to graduate and undergraduate project students and provide supervision of these students within the laboratory. The successful applicant will be expected to present at internal group meetings and will have the opportunity to attend external scientific meetings and to contribute to drafting manuscripts for the publication of the project studies. There will be scope for further research training through courses run both within the University and externally, for example in computational biology.

The successful applicant will hold, or be near to completion of a relevant PhD/DPhil degree, and have experience in molecular/cellular biology relevant to the programme of work. They must be strongly motivated with a highly enthusiastic approach to science and good organizational, verbal, communication, and interpersonal skills. They must be able to work both independently and part of a research team. It is desirable (but not essential) that the successful applicant has experience in cardiovascular research working with animal models. Experience of histology and gene/protein expression analyses and confocal microscopy with image analysis software would be beneficial.

The successful applicant will be based at the Institute of Developmental and Regenerative Medicine (IDRM), IMS-Tetsuya Nakamura Building, Old Road Campus, Oxford, OX3 7TY.

The position is for a fixed term of 30 months from 1 July 2024 or as soon as possible thereafter, funded by a generous donation from Jesus College, Oxford.

Applicants should complete the online form by 12 noon on Monday, 8 January 2024.

The College will seek references at a shortlisting stage. There is no need for referees to send in a reference prior to being contacted.

It is anticipated that interviews will take place on Monday, 5 February 2024. If interviews are conducted in-person, reasonable interview expenses will be reimbursed, and overnight accommodation can be offered if required. Interviews may be conducted remotely.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

Queries may be addressed through the Principal’s PA, Mrs Helen Gee (helen.gee@jesus.ox.ac.uk) or to Professor Paul Riley (paul.riley@idrm.ox.ac.uk).

The Institute and University Community will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally.

Jesus College welcomes and celebrates diversity. We strive towards creating an inclusive environment, where our staff and those associated with the College feel valued and respected. We want them to thrive, regardless of their age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, and sexual orientation. Our staff are an integral part of our community, and we cherish equally those qualities that make each of us unique, and those that bring us together.

Location: Oxford
Salary: £36,024 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th November 2023
Closes: 8th January 2024
   
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