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Research Fellow in Mathematical Oncology

UCL - Mathematics and Statistics

Location: London
Salary: £42,009 per annum, inclusive of London Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 14th November 2023
Closes: 8th January 2024
Job Ref: B04-04312

About us

We welcome a regular stream of distinguished visiting academics from home and abroad. The broad range of research interests is reflected in the large choice of courses available in the third and fourth years of the degree programmes, from spectral theory, groups and geometry to fluid mechanics and from mathematical ideas in biology to cosmology.

About the role

By building a deep understanding of the development of solid cancers in children, applying advanced cellular engineering technologies and performing progressive clinical studies, the NexTGen team seeks to produce effective CAR T-cell therapies for children with sarcomas and brain tumours. Cancer is a leading cause of death by disease in children worldwide. Although survival has increased for some paediatric cancers, such as blood cancers, survival for some solid tumours has seen little improvement for more than 30 years. Standard treatments can cause severe long-term health complications, such as learning difficulties, abnormal growth and infertility. For children who relapse, few second-line treatments are typically available. Many barriers exist to developing specific, effective treatments for children with solid tumours – for example, because adult cancers are very different to childhood ones, therapies that are developed to exploit cancer’s vulnerabilities in adults have limited efficacy in children. The Cancer Grand Challenges NexTGen team aims to overcome these barriers and deepen our understanding of childhood solid cancers, to discover new targets and develop and optimise novel CAR T-cell therapies for children with these diseases. The discoveries may improve survival in children with solid cancers and diminish the lifelong toxicities often experienced by survivors.

For the position as a Research Fellow, we are seeking a highly motivated and talented applicant with experience of mathematical modelling and knowledge of PDEs and individual-based/ hybrid models. Ability to analyse such models analytically and numerically is essential. The project will focus on modelling CAR-T cell therapies for solid paediatric tumours and the influence that the tumour microenvironment has on success/ failure of such therapies. The aim is to predict the factors influencing success of therapy and to suggest experiments to determine if certain interventions can improve success rate.

About you

Please use the 'Apply' button above to read further information about this role including the full job description and person specification. 

What we offer

As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:

  • 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
  • Additional 5 days’ annual leave purchase scheme
  • Defined benefit career average revalued earnings pension scheme (CARE)
  • Cycle to work scheme and season ticket loan
  • Immigration loan
  • Relocation scheme for certain posts
  • On-Site nursery
  • On-site gym
  • Enhanced maternity, paternity and adoption pay
  • Employee assistance programme: Staff Support Service
  • Discounted medical insurance Further Details A job description and person specification can be accessed at the bottom of this page.

To apply for the vacancy please click on the ‘Apply’ button above. 

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