|From £41,935 with benefits, subject to skills and experience.
|27th November 2023
|20th January 2024
Location: The Francis Crick Institute, Midland Road, London
Project summary and the position
Study of molecular pathways of regulation of the immune response to the pathogens Escherichia coli, Citrobacter rodentiium and the pathobionts Helicobacter hepaticus, Enterococcus faecalis in the gut.
The laboratory focuses on the study of the regulation of the immune response during immune challenge and infection, to identify immune cells, pathways and targets of protection and pathogenesis determining disease outcome. A major programme in the lab continues to be to define transcription factors that regulate cytokine gene expression in myeloid cells and T cells, and their consequent function in experimental mouse models in vivo. Collectively, the aims of the lab are to identify immune cells and pathways contributing to protection and pathogenesis in infectious diseases.
The lab uses an extensive set of techniques for studying mucosal immune responses in vivo to infectious pathogens in the blood and tissues, specifically now focussing on the lung and airways (TB) and the gut and periphery (Helicobacter and E. coli) to define immune factors contributing to protection or pathogenesis to infection with pathogens and immunopathology in response to pathobionts
The person(s) successful for these position(s) will conduct in vivo experiments in CD4-transcription-factor-targetted gene deleted mice, and reporter mice available in the lab, as well as other relevant genetically mutated mice, and/or with administration of blocking antibodies, to study the pathways and mechanisms of the immune response regulated by these transcription factors which result in the different forms of colitis in response to oral infection with H. hepaticus, as compared to effects during peripheral or oral infection with pathogens. These findings may then be compared with published studies of human colitis.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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