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Research Associate

University of Glasgow - School of Molecular Biosciences

Location: Glasgow
Salary: £39,347 to £44,263 per annum Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 1st December 2023
Closes: 10th January 2024
Job Ref: 120949

College of Medical, Veterinary and Life Sciences

We have an exciting opportunity for a Research Associate to work on a programme funded by the UKRI-Medical Research Council for 3 years,aimed at development of a new drug discovery platform that will transform the way that we develop drugs of the future. Focused on our exciting cyclic-peptide technology this programme is centred on targeting a G protein coupled receptor (GPCR) for the treatment of severe asthma. Working in collaboration with leading respiratory clinicians and closely with the biotechnology company KelticPharmaTherapeutics Ltd this project is aimed at validating FFAR1 and/or FFAR4 as a novel drug target in the treatment of severe asthma and Chronic Obstructive Pulmonary Disease (COPD) whilst developing a novel GPCR-focused drug discovery platform.

The project builds from our discovery, published in Science Translational Medicine (12, aaw9009 (2020)) that activation of FFAR4 can relieve the symptoms and induce inflammation in pre-clinical mouse models of inflammatory lung disease. Moreover, by studying normal human lung samples and patient-derived lung tissue we have translated the mouse work to human studies that have provided the basis for our hypothesis that activation of FFAR4 can both relieve the symptoms and reduce inflammation in asthma and COPD.This is an opportunity for a highly motivated Research Scientist to conduct basic research with an eye to clinical development.

The candidate will be based at University of Glasgow in state-of-the-art laboratories located in the newly built Advanced Research Centre (ARC) in the heart of the University campus. Working closely with the clinical team based in Leicester and with staff from KelticPharmaTherapeutics the candidate will gain experience in translating fundamental research into a drug discovery programme.

This position is available on a full-time basis and is funded until 30 September 2026.

Informal enquiries may be directed to Professor Andrew Tobin, Andrew.Tobin@glasgow.ac.uk

or Professor Graeme Milligan, Graeme.Milligan@glasgow.ac.uk.

For the full job description and to apply online please click on the ‘Apply’ button above

We believe that we can only reach our full potential through the talents of all. Equality, diversity and inclusion are at the heart of our values. Applications are particularly welcome from across our communities and in particular people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented within the University. Read more on how the University promotes and embeds all aspects of equality and diversity within our community https://www.gla.ac.uk/myglasgow/humanresources/equalitydiversity/ 

We endorse the principles of Athena Swan https://www.gla.ac.uk/myglasgow/humanresources/equalitydiversity/athenaswan/

and hold bronze, silver and gold awards across the University. 

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