Back to search results

Research Fellow

The University of Edinburgh - MRC Human Genetics Unit - Institute of Genetics and Cancer

Location: Edinburgh
Salary: £37,099 to £44,263 per annum (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 10th January 2024
Closes: 27th February 2024
Job Ref: 6305

Full-time, 35 hours per week

Fixed term with the possibility of extension

We have one Postdoctoral research opportunity working within the laboratory of Professor Javier F. Caceres at the MRC Human Genetics Unit in Edinburgh, funded by the Medical Research Council.

The Opportunity

We aim to understand regulatory mechanisms related to the processing and quality control of RNAs in vivo, focusing on the Nonsense-mediated decay (NMD) pathway. NMD targets mutated mRNAs harboring premature termination codons (PTCs) for degradation, but also regulates the stability of many cellular transcripts. Importantly, NMD modulates the phenotypic outcome of genetic disorders caused by frameshift or nonsense mutations that generate PTCs. Thus, a better understanding of its regulation in vivo is needed for designing strategies to modulate the NMD response for therapeutic use (1).

Research objectives

We have developed a novel transgenic mouse model harboring an NMD sensor, which will allow to monitor the efficacy, tissue-specificity, and developmental regulation of the NMD response in vivo, with single-cell resolution. The project will use this mouse model to investigate the complex regulation and physiological relevance of the NMD pathway in vivo. We will also investigate changes in NMD activity in mouse models of human disease. A complementary project will develop genome-wide CRISPR screens in the liver to identify novel regulators of the NMD pathway. There is also the possibility of contributing to complementary projects on the mechanism and function of a localized Nonsense-mediated decay (NMD) response that regulates the expression of transcripts translated at the Endoplasmic reticulum (ER), which we termed ER-NMD(2).

1- Monaghan et al (2023) EMBO J 42e114378

2 - Longman et al. (2020) Genes Dev 34: 1075-1088

For additional lab references, see: Maslon et al (2019) EMBO J 38: e101244; Haward et al. (2021) eLife 10: e65104; Hug et al. (2022) RNA 28: 1224-1238

This position is part of a multidisciplinary team working on the molecular, biochemical, and cellular aspects of RNA processing in eukaryotes. The group is part of the MRC HGU and provides opportunities to develop research project skills and develop collaborative links with colleagues within the Institute and elsewhere. The MRC Human Genetics Unit is a highly multidisciplinary environment and is part of the Institute of Genetics and Cancer (IGC).

Further details of the Research group’s work are available at:
www.ed.ac.uk/mrc-human-genetics-unit/research/caceres-group

Your skills and attributes for success:

  • PhD or equivalent in a relevant scientific discipline
  • Experience in Biochemistry, Cell Biology and RNA processing, in particular related to mRNA translation
  • Experience in embryonic stem cell biology 
  • Ability to communicate complex information clearly, orally and in writing.
  • Expertise in relevant approaches and models, analytical techniques and methods
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from The University of Edinburgh

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge