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Research Associate in C9ALS/FTD Gene Therapy

King's College London - Basic & Clinical Neuroscience

Location: London
Salary: £43,205 to £50,585 per annum, including London Weighting Allowance.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 2nd February 2024
Closes: 14th March 2024
Job Ref: 083665
 

Location: Denmark Hill Campus

Contact details: Younbok Lee. younbok.lee@kcl.ac.uk

Job description

We are seeking a Research Associate who will become an integral member of Dr. Youn-Bok Lee's dynamic research team, which is at the forefront of a gene therapy initiative. This program is dedicated to combating C9orf72-linked amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) and is supported by the My Name’5 Doddie Foundation.  

The mission of the research program is to develop novel vector and refine the dosage of both gene augmentation and silencing vectors within cellular and animal models of these diseases. This is to establish a solid foundation of proof for their efficacy and potential application in clinical settings.

You will collaborate with a dedicated group of Post-doctoral Scientists, Technicians, and PhD students who together will perform analyses on cells and tissues that have been treated with various plasmid and vector constructs, aiming to quantify the impact on the expression of the targeted gene. The role involves spearheading the assessment of innovative plasmid and Adeno Associated Viral (AAV) vectors, as well as confirming their effectiveness in both cellular and animal disease models.

Key technical competencies required for this position encompass a broad spectrum of molecular and cellular biology techniques, including gene cloning, plasmid DNA purification, iPSC cell culture, RNAseq data analysis, CRISPR gene editing, AAV vector production, mouse handling, and the meticulous quantification of vector genomes, mRNA, and protein expression levels.

Conducting experiments to the highest standard of excellence is imperative, as is maintaining the strictest levels of confidentiality with all research data. This position represents a remarkable chance to advance one's career within the cutting-edge field of Gene Therapy, offering a deeply fulfilling professional pursuit for those committed to making a difference in the lives of individuals affected by ALS and FTD. 

This post will be offered on an a fixed-term contract until 31st March 2027.

This is a full-time  post - 100 % full time equivalent.

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