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Research Fellow

The University of Edinburgh - MRC Human Genetics Unit / Institute of Genetics and Cancer

Location: Edinburgh
Salary: £37,099 to £44,263 Grade UE07, per annum, (A revised salary range for this grade of £39,347 to £46,974 is planned to take effect from Spring 2024)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 2nd February 2024
Closes: 1st March 2024
Job Ref: 9583

Fixed-Term: for 2 years

Vacancies available: 2

The Opportunity:

Research Fellow position in Kudla lab at the University of Edinburgh

We have a Research Fellow position available in the group of Grzegorz Kudla at the MRC Human Genetics Unit (MRC HGU), University of Edinburgh, to study the genetics of Parkinson’s disease. 

The post-holder will perform deep mutational scanning of genes associated with Parkinson’s disease. Deep mutational scanning is an experimental approach where you construct a library of mutated genes, transfect the library into an appropriate human cell line, and analyse the effects of mutations by high-throughput sequencing of barcodes.

You will use methods available in the lab (gene synthesis, saturation mutagenesis, high-throughput phenotypic screens, functional genomics) or develop your own methods to understand how mutations influence molecular function and disease phenotypes. You will collaborate closely with experimental and computational biologists at the MRC HGU (University of Edinburgh) and MRC PPU (University of Dundee) to generate your data and use it to train predictive models of Parkinson’s disease.

The positions can be at the level of Postdoctoral Research Fellow (UoE grade 7) depending on the level of experience of the candidate, and is funded by the Michael J Fox Foundation for a fixed period of 2 years. The starting date is on the 1st of April 2024 or as soon as possible after that.

Your skills and attributes for success: 

  • A University degree in molecular, cell or computational biology.
  • Keen interest in working at the interface of experimental and computational science. 
  • Enthusiasm and ability to work as part of a team.
  • Experience in synthetic biology, molecular and cell biology, or functional genomics, including conference presentations and publications in international journals.
  • Interest in the mechanisms of neurodegenerative disease.

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