Back to search results

Postdoctoral Research Assistant UOD1285

University of Dundee

Location: Dundee
Salary: £36,024 to £44,263
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 21st February 2024
Closes: 21st March 2024
Job Ref: 3683

We are looking for an exceptional individual to join the Sapkota Lab as a Postdoctoral Research Assistant to investigate the molecular roles of the FAM83 family of proteins. We have found that FAM83 proteins are the master regulators of CK1 kinases, which themselves are critical for normal cell function and are dysregulated in many diseases, including cancer (PMID: 29789297). We have established that specific FAM83-CK1 interactions are key in controlling a variety of cellular processes ranging from WNT signalling (PMID: 29514862; 33361109; 33361334) to cell division (PMID: 31338967) and can play direct roles in disease pathology (PMID: 31656861).

Given the importance of FAM83-CK1 interactions, it is critical that we now understand the molecular basis of these and determine how specific FAM83 proteins deliver CK1 activity to specific substrates to control CK1 biology. We will employ cutting edge technologies, such as CRISPR/Cas9 genome editing, Cryo-EM & crystallography, mass- spectrometry, and organoid models, in this endeavour. Furthermore, the project aims to use PROTACs and molecular glue degraders to target the degradation of specific FAM83-CK1 complexes as an innovative strategy to inhibit cancer cell proliferation. For details of the Sapkota lab research, please visit sites.dundee.ac.uk/sapkota-lab.

For more information, please contact Gopal Sapkota (gsapkota@dundee.ac.uk).

Your priorities will include:

  • Undertaking research aimed at understanding the molecular basis of FAM83-CK1 interaction by employing structural approaches and developing cell models to dissect the impact of disrupting specific FAM83-CK1 interaction on cell signalling and proliferation, with a particular focus on WNT signalling.
  • Project development and implementation, including experimental design and development of cell lines using CRISPR/Cas9 genome editing. Develop tools and workflows to dissect WNT signalling pathway and consequences of targeted degradation of specific FAM83-CK1 complexes.
  • Performing protein purifications for structural studies and biophysical measurements of protein-protein interactions.
  • Working closely and collaboratively with a team of postdoctoral fellow and PhD students working on different FAM83 proteins.
  • Discussing scientific work at internal meetings, meetings with DSTT industrial partners and at conferences.

Who we’re looking for:

  • PhD with an outstanding track record and at least one first-authored publication in an internationally recognised peer-reviewed journal.
  • Strong background in cell and molecular biology, biochemistry, and signal transduction, with expertise in protein chemistry and reversible protein phosphorylation desirable.
  • Strong background in protein expression and structural biology is desirable.
  • Strong background in WNT signalling and cancer biology is desirable.
  • Capable of working in a diverse team, but able to plan and work independently.
  • Excellent communication skills and proficiency in English.
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from University of Dundee

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge