Postdoctoral Research Associate

This new full time post is available from 1 July 2025 on a fixed term basis until 30 June 2028.

The post

The Faculty wishes to recruit a Postdoctoral Research Associate to support the work of Professor Wendy Noble. You will undertake a project focussed on understanding how molecular properties of tau affect its processing by human astrocytes and affect the astrocyte transcriptome. This Alzheimer’s Research UK funded post is available from 1 July 2025 on a fixed term contract until 30 June 2028.

The successful applicant will lead the characterisation of postmortem human tauopathy brain, differentiation of human iPSC into astrocytes, analysis of human brain tau uptake and processing by astrocytes using high content imaging approaches, and analysis to determine how differential tau processing impacts on astrocyte gene expression and splicing. The candidate will also lead the selection of candidate protein modifications and/or astrocyte signaling pathways that are linked with detrimental phenotypes. These will be explored using pharmacological and/or genetic manipulation to promote tau clearance. which will involve collaboration with our partners who have expertise in mass spectrometry. The candidate will have access to a supportive environment to advance their professional development and the opportunity to learn a range of relevant skills to complement their current skillset in a multidisciplinary department.

About you

The successful applicant will be able to present information on research progress and outcomes, communicate complex information, orally, in writing and electronically and prepare proposals and applications to external bodies.

Applicants will possess a relevant PhD (or nearing completion) or possess an equivalent qualification/experience in a related field of study and be able to demonstrate sufficient knowledge in the discipline and of research methods and techniques to work within established research programmes. Applicants should be trained in neurodegeneration research or a related discipline. Applicants will have prior experience of modelling neurological disease features using iPSC-derived cells and will ideally have expertise in at least two of the following: working with postmortem human brain, molecular biology, microscopy/high content imaging and image analysis and/or transcriptomic data analysis.

Please ensure you read the Job Description and Person Specification for full details of this role.

Further information

For further information please contact Professor Wendy Noble, e-mail w.noble2@exeter.ac.uk.

Interviews are expected to take place soon after the closing date.

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