Postdoctoral Research Associate

About the Role

Applications are sought for an exciting opportunity within the Ciccarelli lab, within the Centre for Cancer Evolution, Barts Cancer Institute.

We are seeking an independent, highly motivated computational Postdoctoral Research Assistant to lead on an established and successful research line aimed at understanding the role of the tumour immune microenvironment (TIME) in response to immunotherapy. This project stems from previous work where we showed that TIME composition determines response to immunotherapy (Bortolomeazzi Gastroenterology 2021) and identified a marker of this ideal TIME using a combination of spatial transcriptomics and immunostaining (Acha-Sagredo Cancer Cell 2025). In parallel, we developed computational methods for the analysis of spatial omics data (Bortolomeazzi Nature Comms 2022) and clustering of rare cell populations (Martens, Bioinformatics 2023).

The post holder will have the main responsibilities of analysing genomics, transcriptomics and spatial transcriptomics and proteomics data and will be integrated within a team within our lab working on this large project.

The Ciccarelli lab is highly collaborative and interdisciplinary and the ability to work in a team is essential.

About You

The successful candidate will be expected to have a PhD degree in biological or computational sciences or equivalent, with solid knowledge of computational coding applied to genomics. Significant research laboratory experience in genomic and transcriptomic computational data analysis is essential, as well as experience in statistics and coding.

About the School/Department/Institute/Project

Our group is based in the Centre for Cancer Evolution at the Barts Cancer Institute and are affiliated with the Francis Crick Institute, a pioneering biomedical research institute in London where our wet lab is located. We are also part of Cancer Research UK City of London Centre, which sponsor our high-performance computer cluster facility.

About Queen Mary

At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.

Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers.

We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.

Benefits

We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities. There is also possibility of offering a market supplement depending on the expertise of the candidate and this will be assessed at the negotiation stage.

Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.

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