Back to search results

Research Fellow

UCL - Department of Neurodegenerative Disease / UK Dementia Research

Location: London
Salary: £43,374 to £51,860
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 30th May 2025
Closes: 26th June 2025
Job Ref: B02-08817

The Research Departments of Neurodegenerative Disease and the UK Dementia Research at UCL are internationally recognised leaders in the study of a wide range of neurodegenerative diseases, including those leading to dementia and neuroinflammation. We have a strong focus on mechanistic dissection of genetic, molecular cellular and neuropathological processes which underlie across the neurodegeneration spectrum.

The laboratory of Dr Salih is dedicated to investigating the interplay between the immune system and cognitive function in the ageing brain focusing on neurodegenerative diseases like Alzheimer's disease. We study genetic variation in the human population and their effects on neurodegenerative diseases using techniques such as GWAS, transcriptomics, and epigenetics. Our interdisciplinary approach integrates molecular biology, biochemistry, cell biology, and advanced genomic methods to advance our understanding and treatment of dementia and age-related disorders.

We are seeking a Research Fellow to join a dynamic team that employs cutting-edge models - including iPSC-based cell biology, screening, biochemistry, genomics, imaging, and bioinformatics - to uncover new mechanistic insights into genes with variants associated with ageing and neurological function.

The overarching goal of the project is to systematically characterise the glial-specific functions of newly identified longevity-associated genes recently published by the Salih lab (https://doi.org/10.1093/brain/awae339) - in models of ageing and Alzheimer’s disease-associated toxicity, and thus to identify which of these genes are most promising for future therapeutic targeting in neurodegenerative diseases.

You will be responsible for planning, execution and report of experiments and contribution to the formulation and submission of research publications as well as management and direction of this challenging project as opportunities allow.

The post is available from 01 August 2025 and is funded by a grant from the Medical Research Council to 31 July 2028 in the first instance.

If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team (ion.hradmin at ucl.ac.uk).

For informal enquiries about the role please contact Dr Dervis Salih (dervis.salih at ucl.ac.uk).

Interviews are scheduled for the week beginning 14 July 2025.

For a full job description and to apply for this role please visit UCL’s online recruitment portal (https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs) and search using vacancy reference B02-08817.

You will hold a PhD (or be near to completion) in Neuroscience, Cell Biology, Immunology, Biochemistry, Molecular Biology or related discipline, with knowledge of iPSC-microglia, neuronal cultures and/or primary cells and molecular mechanisms of neurodegenerative disease, ageing and/or immunology. Experience with siRNA or other genetic manipulation methods, with cell biology and biochemistry, with microscopy and with transcriptomics is also a requirement.

Appointment as Research Fellow is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be as Research Assistant (salary £38,607 - £41,255 per annum) with appointment as Research Fellow being backdated to the date of final submission of the PhD thesis.

As well as the exciting opportunities this role presents, we also offer some great benefits; visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Customer advert reference: B02-08817

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from UCL

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge