Postdoctoral Fellow

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. Click here to learn more.

About the role

Dr. Adrover’s laboratory focuses on how cancer affects whole-body physiology, with a particular emphasis on the cardiovascular, haematopoietic, and immune systems.

The Cancer Macroenvironment Lab is seeking applications for postdoctoral candidates to carry out experimental work aimed at understanding the interplay between cancer and the haematopoietic compartment. The research program will study how cancer affects the haematopoietic stem and progenitor cell compartment to induce changes in myeloid populations that then have detrimental roles in cancer progression. You will be looking at how this happens and how we can target these processes to enhance cancer patient’s welfare. You will be mainly working in a wet lab, although the role will also encompass sequencing data analysis. 

What you will be doing 

As a Postdoctoral Fellow some of your main responsibilities will be: 

• Using murine models of cancer to analyse the hematopoietic stem and progenitor cell compartment in the bone marrow to understand neutrophil differentiation dynamics and how they are affected by growing tumours.
• Studying the precise mechanisms through which cancer communicates with the bone marrow compartment, with the goal of targeting these processes to enhance patient welfare.
• Interrogating how cancer therapy affects haematopoietic stem and progenitor cells. In broader terms, exploring contexts other than cancer in which similar reprogramming of the hematopoietic compartment takes place.
• Using state of the art in vivo intravital imaging as well as ex vivo tissue clearing techniques to study bone marrow niche dynamics. 

The project can be tailored to the interests of the successful candidate. Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis. 

About you 

• PhD in immunology, cancer biology, biochemistry or cell biology or in the final stages of PhD submission
• Knowledge and experience in stem cell biology, immunology or cancer biology
• Technical expertise in mouse work, and experience with experimental design
• Flow cytometry and microscopy experience
• Track record of writing papers as evidenced by publications in peer-reviewed journals 

About Working at the Crick… 

Our values  

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently. 
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. 
• We are collegial. We show respect for one another, work cooperatively and support the wider community. 

At the Crick, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. If you need assistance with your application, please contact weronika.kucala@crick.ac.uk

To read more about our EDI approach, click here.   

What will you receive?  

We value our team members and are proud to offer an extensive range of benefits to support their well-being and development. You can find out more about what we offer here.

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