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Researcher - Investigating the Effects of CO on Platelet Function

Sheffield Hallam University - College of Health Wellbeing & Life Science

Location: Sheffield
Salary: £32,080 to £38,784 per annum, dependent on experience (Grade 6)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 4th August 2025
Closes: 31st August 2025
Job Ref: 113008
 

We’re recruiting for a Postdoctoral Researcher to join us for 12 months to investigate the effects of the environmental pollutant carbon monoxide (CO) on platelet function and signalling: The Role of CO in clotting. This study is funded by the CO Research Trust.

Background: CO is a byproduct of the incomplete combustion of carbon-based fuels, forming when fuels burn in limited oxygen. Common sources include traffic emissions, industrial processes, tobacco smoke, and domestic combustion (e.g. poorly ventilated stoves or heaters). While CO at low concentrations acts as a physiological signalling molecule, elevated environmental exposure is a significant public health concern with well-documented toxic effects, especially on the cardiovascular system.

Project Overview: Platelets are critical regulators of haemostasis and inflammation, and may play a key role in mediating the vascular effects of CO exposure. However, this interaction remains poorly understood. This project aims to determine how environmentally relevant concentrations of CO influence:

  • Platelet activation and aggregation
  • Intracellular signalling pathways
  • Platelet-endothelial cell interactions

The research has implications for understanding cardiovascular disease risk, thrombosis, and systemic inflammation.

Candidate Requirements: You should have completed (or be close to completing) a PhD in Cell Biology, Haematology, or a related discipline, and must have a strong research track record, experience with cell culture model systems, proficiency in flow cytometry, confocal microscopy or other advanced imaging techniques.

Experience in blood handling, platelet biology, haemostasis, or vascular inflammation would be advantageous but not essential.

This 12-month funding will support the expansion of ongoing research within the Stafford and Herigstad Carbon Monoxide (CO) Group. You will join a dynamic and thriving team of CO researchers, including PhD students, postdoctoral researchers, technicians and academic staff, contributing to a collaborative and supportive environment.

The study is led by Dr Prachi Stafford with Dr Mari Herigstad and Dr Caroline Dalton, as collaborators.

You will be based at the Biomolecular Sciences Research Centre (BMRC) at Sheffield Hallam University, which has established expertise in microbiology, cell biology, and mass spectrometry imaging.

This post also offers an excellent opportunity for academic career advancement and you will be part of a wider research community that includes over 40 research students within the BMRC and more than 100 across the College of Health, Wellbeing and Life Sciences.

For informal enquiries about this job, please contact Prachi Stafford, Study lead at p.stafford@shu.ac.uk or Dr Caroline Dalton at c.f.dalton@shu.ac.uk

We offer a diverse range of benefits and opportunities to pursue a rewarding and fulfilling career in a supportive environment. 

You will be contractually enrolled into the Teachers’ Pension Scheme (TPS) – one of the largest and most generous defined benefit pension schemes in the country.

For this job, we particularly welcome applications from minority ethnic applicants who are underrepresented in this area/ this type of job at Sheffield Hallam.

The University may be able to sponsor the employment of international applicants in this role; this will depend on a number of factors specific to the individual applicant.

We welcome applications for flexible working arrangements. 

To find out more, take a look at our guide to applying.

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