Senior Research Scientist in Genetic Manipulation

Location: The Francis Crick Institute, London

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. 

To learn more about the Crick, click here.

About the role

The services that GeMS currently compromises are: molecular biology, micromanipulation, surgical expertise, cryopreservation of rodent and aquatics germplasms, assisted Reproductive techniques such as IVF, AI, ICSI, Rederivation of live and frozen imports & exports to and from the Crick, and murine stem cell culture. 

As the GeMS Senior Research Scientist (SRS), you will play a pivotal role in developing new animal models and leading projects from start to finish. An in-depth understanding of molecular biology, cell culture, genetic modification, and mouse genetics is required. You will also ensure that the 3Rs principles for in vivo research -replacement, reduction, and refinement, underpin all work undertaken. 

What you will be doing 

As a Senior Research Scientist at the Crick, you will:   

• Design and plan complex cloning strategies, genotyping strategies and the generation of molecular reagents, for the production and validation of new genetically modified alleles, predominantly using CRISPR-based genetic manipulation.
• Use, implement, support and troubleshoot the execution of core molecular biology and cell culture techniques and implement novel methodologies within the group to improve production efficiency and accuracy.
• Support the Senior Manager in the design and implementation for the creation of new animal models.
• Plan and co-ordinate the in vivo gene delivery pipeline, for the direct manipulation of the mouse zygote, and the gene targeting pipeline for manipulation of mouse embryonic stem cells.
• Trouble shoot problematic experiments across the GeMS portfolio. 

Please see the full job description here. 

About you 

You will bring 

• PhD or MSc/BSc with a proven track record and significant experience in a relevant field.
• Possess considerable relevant experience with a track record of achievement and demonstrable skill in genome engineering, molecular biology and mammalian cell culture.
• Exhibit knowledge, understanding and practical experience of CRISPR/CAS design and associated techniques.
• Experienced in the use genome browsers, DNA analysis software and CRISPR Cas guide on/off target specificity software.
• Commitment to continued professional development (CPD). 

About Working at the Crick

Our values  

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently. 
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. 
• We are collegial. We show respect for one another, work cooperatively and support the wider community. 

At the Crick, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. If you need assistance with your application, please contact people@crick.ac.uk 

To read more about our EDI approach, click here.   

What will you receive?  

We value our team members and are proud to offer an extensive range of benefits to support their well-being and development. You can find out more about what we offer here.

To apply for this role, please click on the 'Apply' button above.

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