Research Associate (Káradóttir Lab) (Fixed Term)

Fixed-term: The funds for this post in the first instance is are available for 12 months.

The Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The laboratory of Prof. Thóra Káradóttir (https://www.stemcells.cam.ac.uk/people/pi/karadottir) uses multidisciplinary approaches to investigate the effect of myelin changes on neuronal circuit function and the consequences of loss of myelin in neurodegenerative disorders. White matter lesions accumulate in multiple sclerosis (MS) and neurodegenerative disorders, and correlates with cognitive and dexterity impairment. Across these conditions, lesions precede grey matter atrophy and clinical symptoms, suggesting they play a causative role in neurodegeneration. In progressive MS, neurodegeneration is thought to be a consequence of failed myelin regeneration. Hence, myelin regenerative therapies have been identified as effective protection against neurodegeneration in MS and may represent a more widely applicable strategy, given the commonality of white matter lesions across age-related neurodegenerative disorders.

This role will address the hypothesises that focal white matter lesions evoke functional changes in neuronal circuits that regulate myelin regeneration to restore function. Using established methods and in vivo models of white matter lesions, this research programme aims to answer (1) What are the functional consequences of focal white matter lesions on circuits? and (2) What is the role of distal neuroinflammation in regulating circuit function and myelin regeneration? Demonstrating a causative link between white matter lesions and neurodegenerative disorders will reframe therapeutic strategies to improve neuronal health in a range of neurodegenerative conditions. We are looking for a dedicated postdoctoral researcher to join this exciting MRC funded research programme.

Requirements:

Successful applicants should have a PhD in the field of Neuroscience or similar, or be close to the completion of their degree. A strong background in mouse models of disease, stereotaxic surgery, chemogenetics and imaging is essential for this position. Expertise in general areas of microglia and neurodegenerative disorders would be an advantage. It is essential that the post-holder is organised, able to work collaboratively as a member of a team and can communicate effectively and clearly.

Start date is flexible and can be as early as January 2026.

To apply online and to view further information about the role, please click the 'Apply' button above. 

Applicants must have (or be close to obtaining) a PhD. 

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,610) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

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