Postdoctoral Research Fellow

Full time: 35 hours per week

Fixed term: 12 months

The opportunity:

The laboratory of Prof Steven Pollard explores molecular and cellular mechanisms that regulate neural stem cells and how these become deregulated in brain cancers. We now a postdoctoral research position available to explore the transcriptional and epigenetic mechanisms underpinning glioblastoma, with a focus on the SOX family of transcription factors and the role of histone regulation in driving disease. We will explore novel strategies to target the chromatin landscapes using innovative gene therapy approaches.

You will build on our recent discoveries that have identified key transcription factors, regulatory enhancers and epigenetic reconfigurations underpinning glioblastoma. Specifically, you will use a combination of the latest biochemical, genome editing and genomics technologies, to dissect the mechanisms underlying the identity of glioblastoma stem cells and roles of key histone regulatory pathways. This knowledge is also being deployed in our therapeutics discovery programs, with gene therapy strategies aimed at targeting glioblastoma stem cell identity.

These projects build upon our recently reported publications (Cell,�Cell Stem Cell, Nature Genetics�and�Nature Comms). This is a particularly appealing opportunity for recently completed PhD students with a background in cancer genomics and chromatin regulation who may now wish to move into the related field of cancer advanced therapies.

The salary for this post is��41,064 to �48,822�per annum.

Your skills and attributes for success:

• Demonstrated track record in molecular and cellular mechanisms of stem cells, development or cancer, ideally with strong publication record in chromatin regulation and human primary cancer cell line models.
• Good understanding of the fundamental biology of gene regulation, stem cell or cancer biology, with demonstrated expertise in the latest techniques from imaging, genomics, biochemistry or cell biology.
• Past experience, or enthusiasm to develop, bioinformatics skills for analysis of genomics/NGS datasets.
• Ability to work well collaboratively across multiple projects.

Advert information