Postdoctoral Scientist - PNAC - Dr Ana Tufegdzic Vidakovic - LMB 2142

Fixed term for 3 years

Applications are invited for a Postdoctoral Scientist position in the Group of Dr Ana Tufegdzic Vidakovic at the Laboratory of Molecular Biology (LMB). The overall goal of the group is to understand the molecular mechanisms that regulate transcription by RNA polymerase II (Pol II). At least 80% of Pol II molecules that initiate transcription abort before reaching gene end and completing transcription. The lab aims to identify and study the mechanisms that enable Pol II to traverse genes and complete transcription, as well as those that abort this process by removing or destroying Pol II on genes e.g. https://doi.org/10.64898/2025.12.04.692291; https://doi.org/10.1016/j.molcel.2024.11.024.

The goal of this project is to understand the molecular mechanisms by which several newly discovered Pol II clearance pathways (published and unpublished work of the lab) evict or destroy Pol II on genes. The project will combine protein purification, biochemical reconstitution and cryo-electron microscopy to dissect the underlying mechanisms, complemented by cellular approaches in which the laboratory has extensive expertise. The work will involve close collaboration with the Structural Studies Division at the LMB, particularly with the group of Dr Lori Passmore.

As the successful candidate you will have a PhD in a relevant biological discipline (e.g. molecular biology, biochemistry, structural biology) or be due to complete doctoral studies within 6 months of applying. You will have expertise in protein purification, cryo-EM and/or biochemical reconstitution approaches. Experience with cellular methods (e.g. knock-down, generation of knock-out cell lines) would be desirable but is not essential.

This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills.

The LMB has a collaborative working culture and state-of-the-art building based on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. You will be eligible to join our defined benefit pension scheme, a holiday entitlement of 40.5 days (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications. Further information about the benefits available can be found at http://www.discover.ukri.org/benefits-of-working-at-ukri.

The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).

To apply and access full details of the vacancy please click on the ‘Apply’ button above.

If you are unable to apply online please contact us at recruit@mrc-lmb.cam.ac.uk.

Final appointments will be subject to a pre-employment screening.

We actively support equality, diversity and inclusion. We therefore particularly welcome minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We are a disability inclusive employer and encourage disabled people to apply for this role.