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Postdoctoral Fellow - Cellular Mapping of the Human Brain

Wellcome Sanger Institute

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years 

We are looking to appoint a highly motivated postdoctoral fellow in developmental neuroscience to join Omer Bayraktar's new group at the Wellcome Sanger Institute.

Our group will seek to explore the vast cellular diversity of cell types in the human body, with a primary focus in the brain. A remarkable meshwork of neuronal and glial cells lies at the root of our consciousness and exposes us to various neurodevelopmental and psychiatric diseases. To understand human behavior and neurological disorders, we need to understand how all the different neurons and glial cells talk to each other and build a functional brain. However, we lack large-scale approaches that can systemically map molecular interactions between human brain cell types and help identify developmental and disease-relevant developmental pathways.

You will lead an exciting project in mapping cell types and screening glial-neuronal interactions during human brain development. Your primary objectives will be 1) profiling neural cell types in the postnatal human cerebral cortex with single cell/nuclei RNA-sequencing and 2) large-scale identification of protein interactions between cortical glia and neurons. The transcriptomic profiling will be a part of the Human Cell Atlas (HCA) and you will work closely with a growing number of HCA teams at Sanger and elsewhere as well as various neuroscience labs across the UK. On large-scale protein interaction screening, you will collaborate closely with Gavin Wright's group at Sanger.

Your work will help shape the future research questions in the lab and you will be supported to develop your own research projects within the scope of the group's interests. You will also be exposed to related research in spatial tissue mapping and imaging in our group and will be encouraged to participate in the design and planning of these projects.

This is primarily a training post, with associated responsibility of the faculty team leader and Sanger Institute to ensure training is delivered.

Other information 

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date: 2nd September 2018

Location: London
Salary: £31,503 to £39,492 (dependent on experience) plus excellent benefits
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 6th August 2018
Closes: 2nd September 2018
Job Ref: 83167
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