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Postdoctoral Research Associate - Grade 7

University of Liverpool - Clinical Infection, Microbiology & Immunology

Location: Liverpool
Salary: £34,805 to £40,322 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 2nd July 2020
Closes: 9th August 2020
Job Ref: 020110

Closing date: 9th August 2020 23:30

We are seeking an enthusiastic, motivated and creative microbiologist to join a BBSRC-funded project entitled "Prophage host interactions: pulling back the curtains on Pseudomonas puppet masters". This grant is based jointly at the University of Liverpool, working with Dr. Heather E. Allison (Reader in Microbiology), and with Drs Chloe James and Ian Goodhead at the University of Salford in nearby Manchester. This post is one of 2 PDRA posts: one at Liverpool and one at Salford. The successful candidates will work closely together. The post at Liverpool will involve the characterisation of the responses and stimuli of prophage induction, determination of the best conditions for the production of RNASeq libraries to determine differential gene expression, phage purification, the design of functional assays to ascribe biological function to genes and the production and complementation of isogenic mutants to prove biological function. You should have a PhD in microbiology or a highly relevant biology discipline, be familiar with bacteriophages, in vitro models and a variety of molecular biological techniques.

The overall aim of this work will be to elucidate the previously underappreciated impact that prophages have on the fitness and biology of their bacterial hosts. Although P. aeruginosa prophages have repeatedly been implicated in host fitness, the underlying mechanisms are poorly understood. This project seeks to understand how prophages contribute to the biology and behaviour of the Liverpool epidemic strain of P. aeruginosa, LES. Global gene-expression profiling, mutant construction and functional assays will be used to identify functions of prophage genes and regulators and how they influence host traits. The two PDRAs will work together, but on separate tasks throughout the project, but with regular communication and cross-fertilisation of ideas and skills. The Salford-based post will be focused on the bioinformatic analyses of genomic and transcriptomic data.

The post is available to commence on 1st September 2020 and runs for 36 months.

For full details and to apply online, please visit: recruit.liverpool.ac.uk

020110_job description

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