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Research Fellow

The University of Edinburgh - MRC Human Genetics Unit - Institute of Genetics and Cancer

Location: Edinburgh
Salary: £34,304 to £40,927 (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd August 2021
Closes: 27th October 2021
Job Ref: 1889
 

Full time, 35 hours per week

Fixed term for 3 years

We have one Postdoctoral research opportunity working within the laboratory of Professor Javier F. Caceres at the MRC Human Genetics Unit in Edinburgh, funded by the Medical Research Council.

Background

Our research focuses on the role of RNA-binding proteins (RBPs) in the regulation of gene expression at the post-transcriptional level. We are particularly interested in understanding how alterations to the RNA processing cascade contribute to human disease.

Research objectives

We have recently identified a localized Nonsense-mediated decay (NMD) response that regulates the expression of transcripts translated at the Endoplasmic reticulum (ER), which we termed ER-NMD (1). We aim to investigate the mechanism of ER-NMD, identify the role of ER-localized and canonical NMD factors and define the kinetics of NMD degradation of transcripts translated at the ER. We will also focus on the physiological role of this ER-localized pathway, as well as on the biological consequences of manipulating its activity in relation to cellular stress and its impact on human disease. There is also the possibility of focusing on complementary projects on the role of DExH/D RNA helicases in Alternative splicing and NMD.

1- Longman et al. (2020) Genes Dev 34: 1075

For additional lab references, see: Hug and Cáceres (2014) Cell Rep, 8: 1845; Melero et al (2016) Nat. Commun 7: 10585; Maslon et al (2019) EMBO J 38: e101244; Haward et al. (2012) eLife 10:e65104.

This position is part of a multidisciplinary team working on the molecular, biochemical, and cellular aspects of RNA processing in eukaryotes. The group is part of the MRC HGU and provides opportunities to develop research project skills and develop collaborative links with colleagues within the Institute and elsewhere. The MRC Human Genetics Unit is a highly multidisciplinary environment and is part of the Institute of Genetics and Cancer (IGC)

Further details of the Research group’s work are available at:
www.ed.ac.uk/mrc-human-genetics-unit/research/caceres-group

Qualifications required

Prospective candidates should hold a Ph.D. (or near completion) or equivalent in a relevant science subject and have proven previous experience in molecular and cell biology and biochemistry with a keen interest in RNA biology and Gene expression. The Human Genetics Unit has facilities and expertise in a wide range of disciplines; more information on the research in the Unit can be found at www.ed.ac.uk/mrc-human-genetics-unit

For more information and to submit an application, please visit the University of Edinburgh’s website via the below link.

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